Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The COVID-19 pandemic placed the field of vaccinology squarely at the center of global consciousness, emphasizing the vital role of vaccines as transformative public health tools. The impact of vaccines was recently acknowledged by the award of the 2023 Nobel Prize in Physiology or Medicine to Katalin Kariko and Drew Weissman for their seminal contributions to the development of mRNA vaccines. Here, we provide a historic perspective on the key innovations that led to the development of some 27 licensed vaccines over the past two centuries and recent advances that promise to transform vaccines in the future. Technological revolutions such as reverse vaccinology, synthetic biology, and structure-based design transformed decades of vaccine failures into successful vaccines against meningococcus B and respiratory syncytial virus (RSV). Likewise, the speed and flexibility of mRNA vaccines profoundly altered vaccine development, and the advancement of novel adjuvants promises to revolutionize our ability to tune immunity. Here, we highlight exciting new advances in the field of systems immunology that are transforming our mechanistic understanding of the human immune response to vaccines and how to predict and manipulate them. Additionally, we discuss major immunological challenges such as learning how to stimulate durable protective immune response in humans.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736809 | PMC |
| http://dx.doi.org/10.1016/j.cell.2024.07.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Respiratory and gastrointestinal infections among Hajj pilgrims during the 2012-2025 seasons: A systematic review.
J Infect Public Health
September 2025
Department of Nursing, College of Nursing and Health Sciences, Jazan University, Jazan 82911, Saudi Arabia; School of Medicine, Universidad Espiritu Santo, Samborondon 091952, Ecuador. Electronic address:
Introduction: Hajj is the largest annual mass gathering in the world, attracting more than 2 million pilgrims from 184 countries. Adverse climatic conditions and close proximity of pilgrims during Hajj rituals create a facilitating environment for the transmission of infectious agents, including multi-drug resistant organisms. Although, several individual reports have been published on specific type of infections, there is a paucity of published work reflecting the overall picture of the prevalence of pathogenic infections during Hajj.
View Article and Find Full Text PDFParental vaccine hesitancy among mothers in Georgia: the role of trust in science, government, and religion.
J Public Health (Oxf)
September 2025
Alte University, International School of Medicine, 2 University St, Tbilisi, Georgia, 0177.
Background: Parental vaccine hesitancy (VH) remains a public health concern in Georgia, where misinformation and distrust continue to hinder routine childhood immunization. VH is shaped by psychological, sociocultural, and informational factors, including trust in science, public authorities, and religious institutions. This study examined whether trust-related variables were stronger predictors of VH than traditional sociodemographic characteristics.
View Article and Find Full Text PDFDeveloping Community-Informed Communication Resources to Improve Human Papillomavirus Vaccine Uptake in Tonga.
Health Expect
October 2025
Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Introduction: Despite high coverage of routine childhood vaccines, uptake of the human papillomavirus (HPV) vaccine in the Pacific Island nation of Tonga has been slow. Culturally appropriate communication resources on the importance, safety, and effectiveness of the HPV vaccine are critical to support acceptance and uptake. To develop these resources, it is important to understand what people want to know.
View Article and Find Full Text PDFRoman Catholic Religious Affiliation and Reactions to the Initial Stage of the COVID-19 Pandemic in Poland.
J Relig Health
September 2025
Center for Climate Action and Social Transformations (4CAST) Institute of Psychology, SWPS University, Warsaw, Poland.
The present study examined responses to COVID-19 at the beginning of the pandemic, April 2020, among a representative sample of 880 Poles. Participants described their religious beliefs, their emotional reactions to the pandemic, the changes they had made in their behavior since the onset of the pandemic, and their political orientation (left-right). Roman Catholics felt more threatened by the pandemic than non-believers, and Catholics reacted more strongly to the pandemic than non-believers in terms of feeling scared, paralyzed by fear, panicked, fearful, sad, woebegone, and lost, whereas there were no such differences on other emotional reactions.
View Article and Find Full Text PDFMultiomics approach to evaluating personalized biomarkers of allergen immunotherapy.
J Allergy Clin Immunol
September 2025
National Heart and Lung Institute, Imperial College London, London, United Kingdom; Frankland and Kay Allergy Centre, UK NIHR Imperial Biomedical Research Centre, United Kingdom.
Recent advancements in genomics and "omic" technologies have ushered in a transformative era referred to as personalized or precision medicine. This innovative approach considers the unique genetic profiles of individuals, along with a range of variability factors, to devise tailored disease treatments and prevention strategies that cater to the distinct needs of each patient. Although the terms personalized medicine and precision medicine are frequently utilized interchangeably, it is essential to delineate the subtle distinctions between them.
View Article and Find Full Text PDF