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Objective.: A new critical complication risk analysis, the reasonable risk ratio (RRR or R) for palate surgeries in obstructive sleep apnea patients.
Methods.: Analysis from published meta-analyses, systematic reviews on success rates, and complications encountered for 3 palate surgeries, expansion sphincter pharyngoplasty (ESP), barbed repositioning pharyngoplasty (BRP) and modified uvulopalatopharyngoplasty (mUPPP), over 20 years. The RRR is derived from a ratio of the percentage of each respective complication over the success rate of that particular surgical procedure. The benchmark RRR of tonsillectomy is set at 0.035 to 0.078. An RRR below this benchmark value is more favorable as tonsillectomy is a widely accepted ENT procedure with risks to benefit well accepted.
Results.: The RRR for foreign body (FB) sensation (BRP) ranged from 0.03 to 0.23 (mean RRR of 0.14), FB sensation (ESP) 0.01, FB sensation (mUPPP) ranged from 0.33 to 0.55 (mean RRR of 0.44). The RRR for swallowing difficulties (BRP) ranged from 0.04 to 0.23 (mean RRR of 0.11), mUPPP, was 0.37; no reported swallowing difficulties with the ESP. The RRR for velopharyngeal insufficiency (VPI) (BRP) ranged from 0.009 to 0.18 (mean RRR of 0.07), and RRR VPI (mUPPP) was 0.14. The RRR (BRP) for dry throat was 0.06 and the mUPPP was 0.35, with no reported VPI or dry throat for ESP. The overall RRR for the BRP was 0.09, ESP was 0.01 and mUPPP was 0.29.
Conclusion.: RRR provides a summarized data-driven, statistical guide to aid decision-making, and helps in patient counseling. BRP and ESP have been shown to have less complications compared to mUPPP. IV.
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http://dx.doi.org/10.1177/19160216241279074 | DOI Listing |
Diabetes Res Clin Pract
September 2025
Diabetes Research Group, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia; Department of Endocrinology and Diabetes, Royal Children's Hospital, Melbourne, Victoria, Aus
Aims: To examine 30-year glycemic trajectory in children with early-onset type 1 diabetes (T1D) and ascertain which stages of childhood and adolescence were most contributory to subsequent microvascular disease.
Methods: We recruited children diagnosed with T1D between 1990-1992 into the Cognition and Longitudinal Assessment of Risk Factors over 30 Years cohort study in Australia. HbA was collected from medical records and microvascular complications assessed through self-reports, clinical screenings, retinal photographs, and urinary albumin-creatinine testing.
Background: Preeclampsia/eclampsia places grave barriers to the successful reduction of maternal mortality and morbidity. These barriers have significant adverse outcomes for most women especially in sub-Saharan Africa, with Ghana contributing 88.7% of preeclampsia cases in Africa.
View Article and Find Full Text PDFOrg Biomol Chem
September 2025
Department of Chemical Biology, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, Fujian, China.
Minerals have long been recognized for their role in promoting molecular self-assembly in prebiotic environments by serving as insoluble inorganic scaffolds. However, it remains unclear whether soluble inorganic scaffold molecules, such as polyphosphates, also possess the ability to drive the assembly of small molecules. In this study, carbonyldiimidazole (CDI) was used as a chemical activator in combination with polyphosphates (polyP) to investigate the polymerization behavior of the alkaline amino acid arginine (Arg, R).
View Article and Find Full Text PDFAddict Behav
August 2025
Department of Health Behavior, Policy, and Administration Sciences, University of Nevada, Reno, NV, USA.
Introduction: This study longitudinally describes the relationship between frequency of e-cigarette use and past-month cigarette abstinence, dual use, and maintenance of cigarette smoking among adults in the US who ever used e-cigarettes for cigarette cessation.
Methods: Data were from the US Population Assessment of Tobacco and Health Study Waves 5 (2018/19; baseline) and 6 (2021; follow-up). The sample was restricted to adults who used cigarettes and e-cigarettes in the past-month and ever used e-cigarettes to quit smoking at baseline.
Nutrients
August 2025
School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China.
Childhood metabolic syndrome (MetS) represents a growing public health concern in China, with diet emerging as a critical modifiable risk factor. Although numerous studies have explored the relationship between dietary patterns and MetS, the specific influence of dietary patterns associated with serum uric acid (SUA) levels in the young population remains poorly understood. The purpose of this study is to investigate the relationship between an SUA-related dietary pattern and MetS risk among children aged 9-17 years in Guangzhou, China.
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