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Prompt recognition and management of critical events is pivotal for the provision of safe anesthetic care. This requires a well-functioning team that focuses on effective communication, timely decision-making, and escalation of potential complications. We believe that variation in bedside care leads to "near-misses," adverse outcomes, and serious safety events (SSEs). The principles of an escalation culture have been used successfully in other highly reliable industries such as aviation, military, and manufacturing. We discuss here the introduction of a unique and compelling thought-process for developing an intraoperative escalation protocol that is specifically tailored for our institution. Inspired by a critical intraoperative event, this departmental protocol was developed based on an analysis of multispecialty literature and expert opinion to decrease the incidence of SSEs. It includes a stepwise approach and incorporates patient-specific information to guide team members who encounter dynamic clinical situations. The implementation of the protocol has facilitated continuous quality improvement through iterative education, improving communication, and enhancing decision-making. Concurrently, we have plans to incorporate technology and electronic decision support tools to enhance real-time communication, monitor performance, and foster a culture of safety.
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http://dx.doi.org/10.1213/ANE.0000000000006782 | DOI Listing |
Oral Oncol
August 2025
Department of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA; Robert Ebert and Greg Stubblefield Head and Neck Tumor Center at the Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Genetics, Washin
Background: Management of HPV+ HNSCC with unknown primary (SCCUP) remains controversial. A transoral surgery (TOS) for SCCUP with concurrent neck dissection (ND) has excellent rates of primary lesion detection and removal. This approach allows pathologic staging, directed adjuvant radiation therapy (RT), reduced radiation doses, and decreased rates of chemotherapy.
View Article and Find Full Text PDFJ Neurosurg Pediatr
August 2025
4Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, Washington.
Objective: Fluorescence-guided surgery has been shown to increase the extent of resection in adult high-grade glioma. The peptide-dye conjugate tozuleristide is a fluorescence-guided surgical agent under development to aid in visualization of tumor tissue during CNS tumor resection. The goals of this study were to assess safety, pharmacokinetics, and the fluorescent signal of tozuleristide in primary CNS tumors in pediatric patients with CNS cancers and to determine a recommended dose for phase 2 studies.
View Article and Find Full Text PDFJ Am Coll Surg
August 2025
Northwell Health, Lenox Hill Hospital, Department of Surgery, New York, NY.
Background: Surgical complications impact quality-of-life and escalate healthcare costs. Intraoperative performance, accounting for 40-60% of adverse events, is often judged through visual cues. The accuracy of this in predicting postoperative outcomes remains underexplored.
View Article and Find Full Text PDFJ Neurosurg Pediatr
August 2025
1Department of Neurosurgery, UMass Chan Medical School.
Objective: Stereotactic gene therapy in children is challenging due to the fragility of the infant skull and long hours of infusion. The thalamus, an integrative hub for the entire cortex, has been shown to facilitate widespread gene/protein delivery via axonal transport. The aim of this study was to evaluate the safety and accuracy of bilateral thalamic convection-enhanced delivery (CED) of adeno-associated virus (AAV) vectors for GM2 gangliosidoses in children and to assess outcomes based on post-infusion imaging.
View Article and Find Full Text PDFBMC Infect Dis
August 2025
Department of Cardiovascular Surgery, Kyushu University, Fukuoka, Japan.
We report a rare case of a 41-year-old woman with infective endocarditis (IE) after infertility treatment, mimicking ANCA-associated vasculitis. is a nutritionally variant streptococcus found in human microbiota, rarely causing IE. The patient had undergone four unsuccessful oocyte retrieval cycles and discontinued treatment.
View Article and Find Full Text PDF