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Traumatic pancreaticobiliary injuries are challenging to diagnose and manage. Endoscopic retrograde cholangiopancreatography (ERCP) has potential diagnostic and therapeutic utility in cases of traumatic pancreaticobiliary injuries. In this single-center retrospective study, we assessed 25 cases of abdominal trauma in which the patients underwent ERCP for management of suspected pancreaticobiliary injuries. We analyzed basic patient demographics, mechanism of trauma, method of diagnosis, ERCP results, surgical treatments, and outcomes. Of the 25 assessed patients, 12 (48%) had pancreatic injuries, 12 (48%) had biliary injuries, and 1 (4%) patient had both. The median age was 28 years [IQR 25-35], and 84% of patients were males. Fifty-six percent of injuries were from blunt trauma, while 44% were from penetrating trauma. In cases of ERCP-confirmed biliary leaks (n=11), 100% of leaks were resolved in the 8 patients who underwent repeat ERCP after initial ERCP with stenting. In cases of ERCP-confirmed pancreatic duct leaks (n=10), 57% of duct leaks were resolved in the 7 patients who underwent repeat ERCP after initial ERCP with stenting. One patient in the biliary trauma cohort developed post-ERCP pancreatitis and sepsis. ERCP was a useful diagnostic and therapeutic intervention in this population of patients with pancreaticobiliary trauma.
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http://dx.doi.org/10.31486/toj.24.0040 | DOI Listing |
Probiotics Antimicrob Proteins
July 2025
Department of Gastroenterology, General Hospital of Northern Theatre Command, 83 Wenhua Road, Shenyang, Liaoning, 110840, China.
Severe acute pancreatitis (SAP), a widespread inflammatory condition impacting the abdomen with persistent organ dysfunction (> 48 h) and a high mortality rate, poses challenges due to its unclear pathogenesis and the absence of effective treatment options. Chitooligosaccharide (COS), a naturally occurring alkaline oligosaccharide, demonstrates robust anti-inflammatory, antioxidant, and regulating intestinal microbiota properties. However, the specific protective impact of COS on SAP remains to be fully elucidated.
View Article and Find Full Text PDFInt J STD AIDS
August 2025
Department of Infectious Diseases, Teine Keijinkai Hospital, Sapporo, Japan.
Syphilis is known for its diverse and often deceptive clinical manifestations, yet its potential to elevate tumor markers such as carbohydrate antigen 19-9 (CA19-9) remains underrecognized. We report two cases of secondary syphilis, each presenting with markedly elevated CA19-9 levels in the absence of malignancy. Both patients exhibited cholestatic liver enzyme elevations, and neither had structural abnormalities in the pancreaticobiliary system.
View Article and Find Full Text PDFEndosc Int Open
March 2025
Division of Gastroenterology, Hepatology & Nutrition, University of Minnesota Medical Center, Minneapolis, United States.
Risks of pancreaticobiliary tissue damage secondary to electrical conduction along cannulation wires in the vicinity of electrocautery have rarely been independently studied and remain mostly a theoretical issue. We aimed to evaluate heat generated by commercially available guidewires in the setting of currents used for sphincterotomy to assess their safety during endoscopic procedures. We tested heat generation from 11 common guidewires used in endoscopic retrograde cholangiopancreatography using an electrosurgical generator in combination with a thermocouple temperature probe in an ex vivo model.
View Article and Find Full Text PDFJ Inflamm Res
January 2025
Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People's Republic of China.
Purpose: Explore the therapeutic effect and molecular mechanism of rhein on severe acute pancreatitis associated acute lung injury (SAP-ALI).
Methods: The SAP-ALI rat model was constructed by retrograde injection of 5% sodium taurocholate into the pancreaticobiliary duct, and pulmonary microvascular endothelial cell (PMVEC) injury model was induced by LPS. The potential therapeutic effects and appropriate dosages of rhein on SAP-ALI and PMVEC were investigated in both in vivo and in vitro experiments.
Int J Surg Case Rep
February 2025
Department of Surgery, Inje University Haeundae Paik Hospital, 875 Haeundae-ro, Haeundae-gu, Busan 48108, Republic of Korea. Electronic address:
Introduction: Gastrointestinal stromal tumors (GIST), which occur anywhere in the gastrointestinal (GI) tract, typically occur in the stomach and small intestine but rarely in the duodenum. We present a case report wherein a descending duodenal GIST was treated with a limited, minimally invasive surgery after endoscopic nasobiliary drainage (ENBD) insertion.
Presentation Of Case: A 67-year-old woman visited our hospital with an incidentally discovered duodenal tumor.