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Bovine Respiratory Disease (BRD) poses a significant threat to cattle welfare worldwide, affecting their respiratory system and causing substantial economic losses. BRD is multifactorial in nature. This research aimed to investigate the serological profile of calves for the five main bovine respiratory pathogens. Serum samples were collected from dairy calves aged 7-12 months that had never been vaccinated against tested pathogens and had recently shown signs of BRD. A total of 4095 calves from 650 dairy herds located in south-western Poland were examined. The Commercial Indirect Respiratory ELISA Kit Multiplexed-Double well-BIO K 284/5 (Bio-X Diagnostics, Rochefort, Belgium) was used to determine the presence of antibodies against BVDV, BoAHV1, BRSV, BPIV3, and . The presence of antibodies against at least one of the tested pathogens was found in 306 (47.08%) herds. The overall prevalence of antibodies was as follows: BoAHV1 21.54%, BVDV 32.0%, BRSV 34.15%, BPIV3 34.31%, and 31.38%. The strongest correlation was between BRSV antibodies positive sera and BPIV3 antibodies positive sera. Among the five pathogens tested, antibodies to BVDV, BRSV, BPIV3, and were most commonly detected simultaneously. The results of this study indicate the need for preventive measures against these pathogens in the studied region.
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http://dx.doi.org/10.3390/ani14172520 | DOI Listing |
Transpl Immunol
September 2025
Molecular and Transplant Immunology Laboratory, Department of Transfusion Medicine (Blood Center), Medanta-The Medicity, Gurgaon, Haryana, India.
Over 60 % of kidney transplant candidates are non-sensitised while remaining 40 % are sensitised because of previous exposure to human alloantigens during previous transplants, blood transfusions, and pregnancy in women. Pre-transplant compatibility testing is mandatory prior to renal transplantation for detecting the presence of donor-specific antibodies (DSAs), which are associated with early hyperacute/acute and later chronic rejections. Initially, complement-dependent cytotoxicity crossmatch (CDCXM) was used as a traditional method for detecting preformed DSAs.
View Article and Find Full Text PDFVirus Res
September 2025
Pennsylvania Department of Agriculture, Pennsylvania Veterinary Laboratory, Harrisburg, PA 17110, USA. Electronic address:
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is capable of infecting multiple species through human-to-animal spillover. Human to animal spillovers have been documented both in domestic and wild animal species. Due to close contact in shared households, pet dogs may be at increased risk for contracting the SARS-CoV-2 virus from infected individuals in the same household.
View Article and Find Full Text PDFMult Scler Relat Disord
September 2025
Neurologist-Neuroimmunologist. Associate Professor of Neurology, Neuroscience Department, Division of Neurology, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá, Colombia. Electronic address:
Background: Headache is a common but underrecognized symptom in optic neuritis (ON), with potential implications for diagnosis and management.
Objective: To assess the clinical and radiological factors associated with headache in patients with acute ON.
Methods: We conducted a retrospective case-control study in a tertiary hospital in Bogotá, Colombia (2022-2024).
Clin Exp Metastasis
September 2025
Medical Oncology Unit, Macerata Hospital, Macerata, Italy.
Recent years have seen the development and advent of novel combinatorial strategies based on immunotherapy, and immune checkpoint inhibitor (ICI) - based treatment has established itself as a mainstay in the treatment of metastatic urothelial carcinoma (UC). Herein, we aimed to validate the prognostic value of a previously developed score, the Prognostic Immunotherapy Score (PIS), including female sex, Eastern Cooperative Oncology Group Performance Status (ECOG-PS) and liver metastases, in patients treated with pembrolizumab for advanced UC from the ARON-2 dataset. We retrospectively analyzed clinical data from Metastatic UC patients diagnosed at age ≥ 18 years.
View Article and Find Full Text PDFAm J Vet Res
September 2025
MiraVista Diagnostics, Indianapolis, IN.
Objective: The aim of this study was to investigate Histoplasma seroprevalence and associated risk factors in free-roaming cats from 2 endemic regions: north central Oklahoma and eastern Tennessee.
Methods: Seroprevalence was determined using frozen serum samples from trap, neuter, release programs in Tennessee (n = 426) and Oklahoma (200) from 2013 to 2024. For Tennessee samples, those with complete signalment information were included.