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http://dx.doi.org/10.1113/JP286706 | DOI Listing |
J Physiol
August 2025
Chair of Continuum Mechanics, Ruhr University Bochum, Universitätsstraße 150, Bochum, Germany.
Piezo1 ion channels are voltage-modulated, stretch-activated ion channels involved in a variety of important physiological and pathophysiological processes, as, for example, cardiovascular development and homeostasis. Since their discovery, it has been known that this type of ion channel desensitizes when exposed to stretch. However recent experiments on Piezo1 ion channels have uncovered that their stretch response is qualitatively different when exposed to positive electrochemical driving forces, where the desensitization is reset.
View Article and Find Full Text PDFJ Nanobiotechnology
February 2025
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Engineering Research Center of Trusted Behavior Intelligence, Ministry of Education, Tianjin Key Laboratory of Intelligent Robotic (tjKLIR), Institute of Robotics and Automatic Information System (IRAIS), Nankai
The regulation of cardiac cell beating is of great significance for understanding cardiac coordination mechanisms and the treatment of cardiovascular diseases. Inspired by this natural "cell regulates cell" mode in which sinoatrial node cells regulate atrial myocytes, this study presented a novel method to replicate this behavior in vitro through mechanical stimulation. Primary cardiac cells from Sprague-Dawley rats were isolated, cultured in 2D substrates, and applied to precise mechanical stimulation by developing a micro-manipulation platform.
View Article and Find Full Text PDFJ Physiol
September 2024
Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada.
Biosensors (Basel)
April 2024
Physiology and Cell Dynamics Group, Instituto de Biomedicina de la Universidad de Castilla-La Mancha, Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, C/Almansa 14, 02006 Albacete, Spain.
J Physiol
September 2024
Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.