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Background: The PedsQL™ 4.0 Generic Core Scales (GSC) have been translated into over 60 languages, but use in the sub-Saharan African region is limited. This study aimed to cross-culturally adapt and validate the PedsQL™ 4.0 GCS child self-report and teen self-report versions into the Chichewa language for Malawi.
Methods: The English (USA) versions were adapted (translation, back translation and cognitive interviews to evaluate conceptual equivalence) into Chichewa. We recruited 289 children (8-17 years) in Blantyre, Malawi. Classical psychometrics at the item level (missing data, endorsement frequencies, item redundancy) and scale level (internal consistency, convergent, discriminant and known groups validity) was used to evaluate the new Chichewa versions.
Results: Six items were found to need cultural adaptation for Malawi. There were problems with missing data (< 5%) and adjacent endorsement frequency (< 10%) among younger children. Internal consistency reliability was acceptable (Cronbach α > 0.7). Convergent validity was generally strong (correlations > 0.4). Discriminant validity (p > 0.05) was evident with respect to gender and age, but not for school grade (p < 0.05). Effect sizes indicating known groups validity were in the expected direction but of variable magnitude.
Conclusion: We have successfully adapted the PedsQL™ 4.0 GCS child self-report and teen self-report into Chichewa for use in Malawi. Many aspects of the psychometric evaluation were promising, though some elements were more mixed and we have not yet been able to evaluate test-retest reliability or responsiveness. We suggest that the PedsQL™4.0 GCS child and teen self-reports should be used with caution among children and adolescents in Malawi.
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http://dx.doi.org/10.1186/s41687-024-00761-5 | DOI Listing |
Ann R Coll Surg Engl
September 2025
Introduction: Surgical training is expensive. The aim of this study was to quantify the costs surgical trainees are expected to pay related to the ten surgical specialties in a single Statutory Education Body (SEB).
Methods: Intercollegiate Surgical Curriculum Programme (ISCP) and Joint Committee on Surgical Training (JCST) certification requirements including mandatory and highly recommended courses, related to specialty, along with professional registration and examination fees were estimated.
J Magn Reson Imaging
September 2025
Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan.
Background: Automated cardiac MR segmentation enables accurate and reproducible ventricular function assessment in Tetralogy of Fallot (ToF), whereas manual segmentation remains time-consuming and variable.
Purpose: To evaluate the deep learning (DL)-based models for automatic left ventricle (LV), right ventricle (RV), and LV myocardium segmentation in ToF, compared with manual reference standard annotations.
Study Type: Retrospective.
Korean J Med Educ
September 2025
Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Purpose: To develop and validate a structured oral clinical assessment (SOCA) tool to evaluate pharmacotherapy competencies among medical students during clinical clerkships.
Methods: The instrument was designed around seven core pharmacotherapy domains. A total of 30 pharmacology experts participated in the face and content validity assessments.
Anal Chim Acta
November 2025
The Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE) - the Portuguese Research Centre for Sustainable Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal. Electronic address:
Background: When using semiconductor quantum dots (QDs) for single-analyte sensing, recognition is commonly achieved through interactions with capping ligands attached to the QDs surface. These ligands form an organic layer that provides stability in solution and assures selectivity by binding the target analyte via surface functional groups. However, a common analytical challenge arises in the subsequent stage of the QD-based sensing scheme.
View Article and Find Full Text PDFClin Nutr ESPEN
September 2025
Department of Epidemiology, University of Iowa, Iowa City, IA.
Background & Aims: People with multiple sclerosis (MS) may be predisposed to malnutrition as several malnutrition risk factors are common among this group; however, evidence on malnutrition in MS is sparse. Therefore, the aim of the present study is to explore what is known about malnutrition in MS.
Methods: A scoping review was performed in 5 databases (Ovid Medline, Embase, Cochrane Central, Scopus, and the Web of Science Core Collection) in February 2024.