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As the regenerative mechanisms of biological organisms, self-healing provides useful functions for soft electronics or associated systems. However, there have been few examples of soft electronics where all components have self-healing properties while also ensuring compatibility between components to achieve multifunctional and resilient bio-integrated electronics. Here, we introduce a stretchable, biodegradable, self-healing conductor constructed by combination of two layers: (i) synthetic self-healing elastomer and (ii) self-healing conductive composite with additives. Abundant dynamic disulfide and hydrogen bonds of the elastomer and conductive composite enable rapid and complete recovery of electrical conductivity (~1000 siemens per centimeter) and stretchability (~500%) in response to repetitive damages, and chemical interactions of interpenetrated polymer chains of these components facilitate robust adhesion strength, even under extreme mechanical stress. System-level demonstration of soft, self-healing electronics with diagnostic/therapeutic functions for the urinary bladder validates the possibility for versatile, practical uses in biomedical research areas.
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http://dx.doi.org/10.1126/sciadv.adp9818 | DOI Listing |
Biosensors (Basel)
August 2025
Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea.
This study presents the development and the mechanical and clinical characterization of a flexible biodegradable chitosan-glycerol-graphite composite strain sensor for real-time respiratory monitoring, where the main material, chitosan, is derived and extracted from larvae shells. Chitosan was extracted using a sustainable, low-impact protocol and processed into a stretchable and flexible film through glycerol plasticization and graphite integration, forming a conductive biocomposite. The sensor, fabricated in a straight-line geometry to ensure uniform strain distribution and signal stability, was evaluated for its mechanical and electrical performance under cyclic loading.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Key Laboratory of Intelligent Textile and Flexible Interconnection of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address:
Human skin exhibits remarkable self-healing and responsiveness, attributed to dynamic disulfide (SS) bonds. However, traditional elastomer polymers often suffer from poor mechanical performance, low stability, and weak signal-capture capabilities due to metastability and insufficient interchain interactions. To overcome these limitations, a novel strategy combining inverse vulcanization and iron(III)-carboxylate coordination was proposed to construct a multifunctional, recyclable elastomer named PTCFe.
View Article and Find Full Text PDFMolecules
July 2025
Department of Polymer Materials Engineering, Shenkar College of Engineering, Design and Art, Anna Frank 12, Ramat-Gan 6262528, Israel.
Biodegradable polymers offer environmental advantages compared to fossil-based alternatives, but they currently lack the stretchability required for demanding applications such as mesh fabrics for woven flexible intermediate bulk container (FIBC) bags and stretch, shrink, and cling films. The goal of this research is to enhance the stretchability of biodegradable blends based on 80% poly(butylene adipate-co-terephthalate) (PBAT) and 20% poly(lactic acid) (PLA) through reactive extrusion. Radical initiator (dicumyl peroxide (DCP)) and chain extenders (maleic anhydride (MA), glycidyl methacrylate (GMA)) were employed to improve the melt strength and elasticity of the extruded films.
View Article and Find Full Text PDFSmall Methods
July 2025
Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 100084, China.
In the context of deepening interdisciplinary research and increasing public health awareness, self-powered technology based on piezoelectric materials has gradually attracted attention in the field of health monitoring and treatment owing to its wireless and passive nature. Sustainable development has prompted the development of degradable piezoelectric materials. However, most degradable piezoelectric materials cannot be applied to active parts of the human body because of their poor strain capacity and toughness.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
July 2025
School of Applied Sciences and Technology, Gujarat Technological University, Chandkheda Ahmedabad, Gujarat, India. Electronic address:
Wearable biosensors have emerged as transformative instruments for continuous, non-invasive health monitoring, providing real-time analysis of biomarkers in biofluids such as sweat, interstitial fluid, and saliva. This chapter offers a comprehensive overview of the pivotal role of biomaterials in the design and functionality of wearable biosensors. It examines the selection criteria for biocompatible materials, emphasizing properties such as flexibility, stretchability, conductivity, and long-term stability.
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