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A method for enhancing the resolution of 3D imaging reconstruction by employing the polarization modulation of electro-optical crystals is proposed. This technique utilizes two polarizers oriented perpendicular to each other along with an electro-optical modulation crystal to achieve high repetition frequency and narrow pulse width gating. By varying the modulation time series of the electro-optical crystal, three-dimensional gray images of the laser at different distances are acquired, and the three-dimensional information of the target is reconstructed using the range energy recovery algorithm. This 3D imaging system can be implemented with large area detectors, independent of the an Intensified Charge-Coupled Device (ICCD) manufacturing process, resulting in improved lateral resolution. Experimental results demonstrate that when imaging a target at the distance of 20 m, the lateral resolution within the region of interest is 2560 × 2160, with a root mean square error of 3.2 cm.
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http://dx.doi.org/10.3390/mi15081023 | DOI Listing |
Beilstein J Org Chem
August 2025
Department of Chemistry, Institute of Natural Sciences, Federal University of Lavras, 37200-900, Lavras, MG, Brazil.
Cyclopropane is a significant alicyclic motif, widely utilized in medicinal chemistry, while fluorination serves as a powerful tool to modulate properties that enhance the performance of pharmaceuticals and materials. This quantum-chemical study explores the energetic implications of fluorinating cyclopropane, providing insights into molecular characteristics arising from the polar C-F bond. Isodesmic reactions revealed that the conversion of cyclopropane and methyl fluoride into mono-, di-, tri-, tetra-, penta-, and hexafluorinated cyclopropanes is exothermic, except for the all--1,2,3-trifluorocyclopropane ().
View Article and Find Full Text PDFImmunol Lett
September 2025
Department of Clinical and Translational Science, College of Graduate Health Science, University of Tennessee Health Science Center, Memphis, Tennessee. Electronic address:
Background: Patients with chronic lung diseases often suffer from pulmonary aspergillosis, caused by Aspergillus fumigatus (AF). Alveolar macrophages play a key role in the initial immune response to AF. Azithromycin (AZM), commonly known for its immunomodulatory properties in reducing exacerbations and improving lung function, has mixed effects on the development of aspergillosis.
View Article and Find Full Text PDFCancer Lett
September 2025
State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Tianjian Laboratory of Advanced Biomedical Sciences, Department of Radiology, Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou,
The tumor microenvironment (TME) plays a pivotal role in cancer progression, though the molecular regulators governing its immunosuppressive properties remain incompletely characterized. In this study, we identify Makorin-2 (MKRN2) as a novel modulator of TME remodeling through integrated analyses of genetically engineered mouse models and human clinical data. Utilizing MKRN2 knockout mice, we observed significantly accelerated tumor growth compared to wild-type control, which was associated with profound alterations in immune cell composition, especially M2 macrophages.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Basis Dis
September 2025
Department of Orthopaedics, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, No.466 Xingang Road, Haizhu District, Guangzhou, 510317, PR China; Southern Medical University, No. 1023-1063, Satai South Road, Baiyun District, Guangzhou, 510515, PR China. Electronic addre
Background: Bone infection induces a strong inflammatory response and leads to impaired bone regeneration, in which macrophages sense mechanistic signals and modulate immune responses in the inflammatory microenvironment through Piezo1. Nonetheless, the regulatory role of Piezo1 in macrophages during bone infection remains elusive.
Methods: Rat models of infected bone defects were established for bulk RNA sequencing and single-cell RNA sequencing.
Int Immunopharmacol
September 2025
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, China-Singapore Belt and Road Joint Laboratory on Infection Research and Drug Development, National Medical Center for Infectious Diseases, Collaborative Innovation Cen
Macrophages play crucial roles in the progression of liver diseases. Increasing studies have shown that mesenchymal stem cells (MSCs) and their extracellular vesicles (MSC-EVs) could reshape the liver immune microenvironment by regulating the function and phenotype of macrophages, thereby exerting a therapeutic effect on liver diseases. Mitochondria, apart from being the central hub of energy metabolism, also finely regulate macrophage-mediated innate immune responses by modulating reactive oxygen species levels, cell polarization, and cell death.
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