Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We aimed to assess the association of SAF with cardiovascular mortality in the general population and the possible association between SAF with other disease-specific mortality rates. We evaluated 77,143 participants without known diabetes or cardiovascular disease. The cause of death was ascertained by the municipality database. The associations between SAF and all-cause mortality, cardiovascular mortality and cancer mortality were assessed with Cox proportional hazard analysis.After a median follow-up of 115 months, 1447 participants were deceased (1.9%). SAF and age-adjusted SAF-z score were higher in all mortality groups. Cox regression analysis revealed that the highest quartile of SAF was associated with increased odds of cardiovascular mortality, (HR) 12.6 (7.3-21.7) and after adjusting for age (HR 1.8 (1.0-3.2)). Significance was lost after additional adjustments for sex, smoking status, and BMI (HR 1.4 (0.8-2.5). For cancer-related mortality the highest quartile of SAF was associated with higher probability of mortality in all models (unadjusted HR 8.6 (6.6-11.3), adjusted for age HR 2.1 (1.6-2.8)), adjusted for age, sex, smoking status, and BMI HR 1.7 (1.3-2.4)). SAF is associated with all-cause mortality as well as cardiovascular and cancer-related mortality in the general population.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11358541 | PMC |
| http://dx.doi.org/10.1038/s41598-024-71037-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inhibition of Interleukin-1 Receptor-Associated Kinase-1 by Pacritinib Is a Therapeutic Strategy to Overcome Melanoma Resistance.
J Environ Pathol Toxicol Oncol
January 2025
Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Despite advancements in systemic therapy, the mortality rate for patients with metastatic melanoma remains around 70%, underscoring the imperative for alternative treatment strategies. Through the establishment of a chemoresistant melanoma model and a subsequent drug investigation, we have identified pacritinib, a medication designed for treating myelofibrosis and severe thrombocytopenia, as a potential candidate to overcome resistance to melanoma therapy. Our research reveals that pacritinib, administered at clinically achievable concentrations, effectively targets dacarbazine-resistant melanoma cells by suppressing IRAK1 rather than JAK2.
View Article and Find Full Text PDFMyxoid spindle cell neoplasm with FET::CREB fusion mimicking meningioma: illustrative case.
J Neurosurg Case Lessons
September 2025
Department of Neurosurgery, St. Francis Hospital & Heart Center, Roslyn, New York.
Background: Myxoid spindle cell neoplasm and meningioma are two different pathologies that can have similar radiographic findings. Despite their benign radiographic appearance, myxoid spindle cell neoplasms are heterogeneous, prone to recurrence, and associated with high mortality.
Observations: The authors present the case of a woman in her late 60s who experienced a witnessed seizure characterized by right arm tonic-clonic movements and subsequent left-sided manifestations.
Financial Burden Experiences of Black/African American Breast Cancer Survivors: A Meta-ethnography.
Cancer Nurs
September 2025
Author Affiliation: School of Nursing, University of Connecticut, Storrs.
Background: Breast cancer is a leading cause of cancer-related morbidity and mortality and imposes substantial financial strain on individuals and society. Minoritized groups, particularly Black/African American (AA) women, face a heightened risk of financial toxicity during treatment, even after accounting for socioeconomic differences.
Objective: The aim of this study was to explore and provide meaningful interpretations of the financial experiences of Black/AA breast cancer survivors (BCSs).
Trends in Status Epilepticus-Related Mortality Disparities in the United States, 1999-2020.
Neurology
October 2025
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
Objectives: Status epilepticus (SE) is a life-threatening neurologic emergency. Although health disparities in epilepsy are well-documented, disparities in SE mortality are not fully understood. This study analyzes mortality trends and demographics in the United States from 1999 through 2020.
View Article and Find Full Text PDFMinimally Invasive vs Open Surgery for Thoracolumbar Fractures in Patients With Ankylosing Spinal Diseases: A Meta-Analysis.
J Am Acad Orthop Surg
August 2025
From the Department of Orthopedic Surgery (Daher, Aoun, Sebaaly), Hotel Dieu de France Hospital, Beirut, LEBANON, the Department of Orthopedic Surgery (Daher, Diebo, Daniels), Brown University, Providence, RI, the Department of Orthopedic Surgery (Daher, Cottrill, Passias), Duke University, Durham,
Background: Surgical management of thoracolumbar fractures in patients with ankylosing spinal disorders such as ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis remains debated. Although several studies have compared minimally invasive surgery to open fixation of thoracolumbar fractures in this patient population, a meta-analysis compiling the literature on this topic is lacking.
Methods: Following the PRISMA guidelines, PubMed, Cochrane, and Google Scholar (pages 1 to 20) were accessed and explored until October 2024.