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http://dx.doi.org/10.1007/s15010-024-02377-9 | DOI Listing |
Eur J Pharm Sci
September 2025
Department of Medicinal Chemistry, Uppsala University, SE-75123 Uppsala, Sweden. Electronic address:
Subcutaneous (SC) injection is the primary alternative to oral administration for therapeutic proteins and peptides. However, bioavailability and absorption rate are often variable and difficult to predict. Therefore, there is a need for new biorelevant and predictive SC in vitro methods.
View Article and Find Full Text PDFMed
August 2025
Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece; Centre of New Biotechnologies and Precision Medicine (CNBPM), School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece. Electronic address: p
Background: Pathogenic responses against self and foreign antigens in systemic autoimmunity and infection, respectively, engage similar immunologic components, thus lacking distinguishing diagnostic biomarkers. Herein, we tested whether whole-blood transcriptome analysis discriminates autoimmune from infectious diseases.
Methods: We applied nested cross-validation methodology to tune and validate random forests, k-nearest neighbors, and support vector machines, using a new preprocessing method on 22 publicly available datasets, including 594 patients with a broad spectrum of systemic autoimmune diseases and 615 patients with diverse viral, bacterial, and parasitic infections.
Forensic Sci Med Pathol
September 2025
Chair and Department of Forensic Medicine, Medical University of Lublin, Lublin, 8B Jaczewskiego st, 20-090, Poland.
This study presents a medico-legal case study of an infant who died as a result of intestinal volvulus, a rare but severe complication secondary to the ingestion of multiple magnets and button batteries. The mutual attraction of magnets through adjacent intestinal loops, compounded by the corrosive effects of button batteries, can precipitate rapid and irreversible damage to the gastrointestinal wall. A comprehensive review of the literature on documented pediatric cases involving the ingestion of magnets and button batteries was undertaken to compare the spectrum and frequency of complications.
View Article and Find Full Text PDFProg Nucl Magn Reson Spectrosc
September 2025
School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom; School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile; Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile; Institute for Biological and Medical
Cardiovascular magnetic resonance (CMR) imaging is an established non-invasive tool for the assessment of cardiovascular diseases, which are the leading cause of death globally. CMR provides dynamic and static multi-contrast and multi-parametric images, including cine for functional evaluation, contrast-enhanced imaging and parametric mapping for tissue characterization, and MR angiography for the assessment of the aortic, coronary and pulmonary circulation. However, clinical CMR imaging sequences still have some limitations such as the requirement for multiple breath-holds, incomplete spatial coverage, complex planning and acquisition, low scan efficiency and long scan times.
View Article and Find Full Text PDFJ Am Soc Echocardiogr
September 2025
Department of Cardiology, University Hospital of Ghent, Ghent University, Ghent, Belgium.
Background: The shape of the continuous wave Doppler (CWD) envelope in functional tricuspid valve regurgitation (fTR) results from the dynamic interplay between flow, pressure gradient and impedance. Although the v-wave cut-off shape in fTR is a well-recognized feature of severe TR, the complete spectrum of TR CWD shapes across the different fTR severity ranges has not been thoroughly explored, which is the scope of the present study.
Methods: In 245 patients with fTR, TR was graded with transthoracic echocardiography using the corrected proximal isovelocity surface area method and CWD shapes were scored, both qualitatively (using visual scoring into parabolic, triangular or v-wave cut-off categories) and quantitatively using a novel Vmax/Vmean parameter and time-to-peak velocity corrected for TR duration (TTP/TRD).