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http://dx.doi.org/10.1016/j.xphs.2024.08.020 | DOI Listing |
J Phys Chem A
September 2025
Department of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14850, United States.
Ionic liquids (ILs) have been gaining increasing focus in a variety of applications including emerging electric-propulsion concepts. A quantitative understanding of how IL ions fragment during high-energy collisions with background gases is therefore essential for interpreting mass spectra, predicting ion lifetimes in plasma and vacuum environments, and designing IL-based technologies. This work uses molecular dynamics (MD) simulations with a reactive force field to numerically model the collision-induced dissociation (CID) of isolated ions (both positive and negative) and ion clusters (2:1 and 1:2 clusters) of the prototypical ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIM-BF), colliding with a nitrogen (N) molecule, exploring all possible fragmentation channels arising from the breaking of both ionic and covalent bonds at collision energies ranging from 10 electron volts (eV) to 100 electron volts (eV) in the laboratory frame.
View Article and Find Full Text PDFPhys Rev Lett
August 2025
Central China Normal University, Key Laboratory of Quark and Lepton Physics (MOE) and Institute of Particle Physics, Wuhan 430079, China.
Diffusion wake accompanying a Mach cone is a unique feature of the medium response to projectiles traveling at a speed faster than the velocity of sound. This is also the case for jet-medium interaction inside the quark-gluon plasma in high-energy heavy-ion collisions. It leads to a depletion of soft hadrons in the opposite direction of the propagating jet and, recently, has been observed in Z-jet events of Pb+Pb collisions at LHC.
View Article and Find Full Text PDFArch Toxicol
September 2025
Department of Toxicology, Faculty of Medicine, Collegium Medicum, Rzeszów University, Al. mjr. W. Kopisto 2a, 35-959, Rzeszow, Poland.
ACP-105 (CAS: 1048998-11-3) is a novel non-steroidal selective androgen receptor modulator (SARM), increasingly detected in anti-doping analyses, yet lacking a comprehensive ADME profile. This study provides the first integrative in silico characterization of ACP-105's ADME properties using seven independent methods (ADMETlab 3.0, ADMET Predictor 12.
View Article and Find Full Text PDFInt J Surg
September 2025
Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: The pathophysiological changes driving incident kidney cancer remain unclear. This study aimed to identify protein biomarkers and underlying mechanisms using pre-diagnostic plasma proteomics.
Materials And Methods: Among 48,851 UK Biobank participants, 165 were diagnosed with kidney cancer, and 2,911 plasma proteins were analyzed.
Ann Clin Transl Neurol
September 2025
Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Background: Plasma p-tau181 has proven to be a promising diagnostic and prognostic tool in the earliest phases of Alzheimer's disease (AD). We aimed to evaluate the prognostic role of p-tau181 in predicting conversion to AD dementia and worsening in cognition in mild cognitive impairment (MCI) and subjective cognitive decline (SCD).
Methods: We consecutively enrolled 163 patients (50 SCD, 70 MCI, and 43 AD-demented (AD-d)), who underwent plasma p-tau181 analysis with the Simoa assay.