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Under the wave of Industry 4.0, traditional pharmaceutical manufacturing enterprises are in urgent need of intelligent manufacturing transformation and upgrading, and exploring the optimal realization path of intelligent manufacturing transformation can help accelerate the transformation process of pharmaceutical manufacturing enterprises. This paper uses grounded theory research methods to conduct a multi-case study to summarize six influencing factors of the intelligent manufacturing transformation of Chinese pharmaceutical manufacturing enterprises; and then analyzes the correlation between the intelligent manufacturing influencing factors based on the DEMATEL method and the NK model, and identifies the key influencing factors according to this, and then draws the fitness landscape map of the intelligent manufacturing transformation, and finally arrives at the optimal path selection of the intelligent manufacturing transformation of pharmaceutical manufacturing enterprises. The study enriches and extends the research paradigm of intelligent manufacturing transformation, and provides lessons for pharmaceutical manufacturing enterprises to realize intelligent manufacturing transformation and upgrading.
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http://dx.doi.org/10.1038/s41598-024-70502-7 | DOI Listing |
J Anesth
September 2025
Community Medicine Education Promotion Office, Faculty of Medicine, Kagawa University Ikenobe, 1750-1, Miki-Cho, Kagawa, 761-0793, Japan.
Generative artificial intelligence (AI) is rapidly transforming perioperative medicine, particularly anesthesiology, by enabling novel applications, such as real-time data synthesis, individualized risk prediction, and automated documentation. These capabilities enhance clinical decision-making, patient communication, and workflow efficiency in the operating room. In education, generative AI offers immersive simulations and tailored learning experiences that improve both technical skills and professional judgment.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Rapid Manufacturing Engineering Center, School of Mechatronical Engineering and Automation, Shanghai University, Shanghai, 200444, China; National Demonstration Center for Experimental Engineering Training Education, Shanghai University, Shanghai, 200444, China; Shanghai Key Laboratory of Intelligen
Osteochondral defects caused by trauma, obesity, tumors, and degenerative osteoarthropathies severely impair patients' quality of life. Multilayer tissue engineering scaffolds offer promising strategies for osteochondral repair by enhancing structural biomimicry. In this study, a triple-layer GelMA-alginate-based osteochondral scaffold (TCOS) was fabricated using an enhanced multi-axis, multi-process, multi-material 3D bioprinting system (MAPM-BPS).
View Article and Find Full Text PDFBiotechnol Adv
September 2025
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; National Engineering Research Center for Fruit and Vegetable Processing, Beijing, China; Key Laboratory of Fruit and Vegetable Processing, Ministry of Agriculture and Rural Affairs, Beijing, Ch
Precision fermentation represents an innovative cell-based production approach that employs synthetic biology and metabolic engineering tools, revolutionizing global food production by utilizing "microbial cell factories" to produce added-value ingredients. However, its global implementation is hindered by technological and scalability bottlenecks, regulatory fragmentation, regional accessibility and consumer acceptance, and nutritional trade-offs challenges. This review utilizes illustrated case studies and modeling analysis to present a detailed exploration of precision fermentation intersecting with global cell-based food production, discussing actionable research gaps and insights as well as advanced bioengineering practices and analytical techniques, to address these challenges for ongoing academic research, industrial applications and policy initiatives, thus supporting the transition of fermentation-enabled food production toward efficient and sustainable manufacturing.
View Article and Find Full Text PDFJMIR Hum Factors
September 2025
Villa Beretta Rehabilitation Center, Costa Masnaga, Italy.
Background: Telerehabilitation is a promising solution to provide continuity of care. Most existing telerehabilitation platforms focus on rehabilitating upper limbs, balance, and cognitive training, but exercises improving cardiovascular fitness are often neglected.
Objective: The objective of this study is to evaluate the acceptability and feasibility of a telerehabilitation intervention combining cognitive and aerobic exercises.
Phys Rev Lett
August 2025
Shanghai Jiao Tong University, State Key Laboratory of Mechanical System and Vibration, Shanghai 200240, China.
Building localized states with high quality factors in compact dynamic systems could enhance the performance of wave control devices such as elastic filters and high-precision sensing devices. Here, we report on the theoretical and experimental investigation of symmetry-protected bound states in the continuum (BICs) in a compressed metaplate. The proposed theory establishes a Bessel-zero-directed multipolarization design that enables precise modulation for the frequencies and modes of BICs.
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