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http://dx.doi.org/10.1016/j.bpj.2024.08.013 | DOI Listing |
Turkiye Parazitol Derg
September 2025
Fırat University Faculty of Fisheries, Department of Aquaculture and Fish Diseases, Elazığ, Türkiye.
Objective: Hirudotherapy (HT), the therapeutic use of medicinal leeches, has been practised for centuries, and the interest in modern medicine has recently been renewed. This study evaluates the clinical outcomes of HT at Herba Medical Center in Azerbaijan between 2020 and 2024, focusing on its efficacy across 11 medical conditions.
Methods: A total of 181 patients were treated using disposable medicinal leeches () sourced from hygienic farms approved by Azerbaijan's Ministry of Ecology and Natural Resources.
The present investigation elucidates the therapeutic potential of glycyrrhizin, the predominant triterpene saponin isolated from (licorice), in the management of systemic lupus erythematosus (SLE), an autoimmune disorder characterized by multisystemic involvement and therapeutic recalcitrance. Comprehensive interrogation of multiple disease-specific databases facilitated the identification of crucial SLE-associated molecular targets and hub genes, with MAPK1, MAPK3, TP53, JUN, and JAK2 demonstrating the highest degree of network centrality. Subsequent molecular docking simulations and binding affinity assessments revealed compounds with exceptional complementarity to these pivotal molecular targets, establishing as a pharmacologically promising botanical source and glycyrrhizin as its principal bioactive constituent meriting comprehensive mechanistic investigation.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Department of Physics and Chemistry, DGIST, Daegu, 42988, Republic of Korea.
Investigation of the fundamental microscopic processes occurring in organic reactions is essential for optimising both organocatalysts and synthetic strategies. In this study, single-molecule fluorescence microscopy was employed to study the Diels-Alder reaction catalysed by a first-generation MacMillan catalyst, providing direct insights into its kinetic dynamics. This reaction proceeds via a series of reversible processes under equilibrium conditions (S ⇄ IM ⇄ IM → P, IM and IM: N,O-acetal and iminium ion intermediates, respectively).
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Geriatrics, Beijing Haidian Hospital, Beijing, China.
The causal relationship between immune cell signatures and multiple myeloma (MM) pathobiology remains incompletely understood. This study aimed to explore the bidirectional causal associations between 731 circulating immune cell traits and MM risk using a two-sample, bidirectional Mendelian randomization (MR) approach. Two-sample MR analyses were conducted utilizing genome-wide association study (GWAS) summary statistics for 731 immune cell phenotypes and MM GWAS datasets.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Although the potential causal associations between cell-derived signaling molecules and sleep disorder (SD) have been reported, contradictions remain. This study assessed the causal effects and the mediating role of 1400 metabolites among 91 cell-derived signaling molecules and SD from a genetic perspective by performing Mendelian randomization (MR) analyses. Genetic instruments derived from publicly available genome-wide association studies were employed in this study, including 49,880 SD cases and 358,194 controls.
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