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Descend and ascend of deep-water human-occupied submersibles based on buoyancy changes are enabled using a denomination of dispensable drop-weights, and loss of buoyancy are managed using emergency drop-weights and jettisoning identified systems. Failing to release the drop weights or jettison results in submersible stranding on the sea floor, leads to emergency recovery, and hence the drop-weight configuration has to be highly reliable. The paper, for the first time, based on hydrostatic stability, descend/ascend velocity needs, ocean salinity profile and loss-of-buoyancy situations, proposes a novel on-demand reliability based methodology for determining the safe drop-weight configuration and degradation-based mission abort strategy for deep-ocean human submersibles. Probabilistic on-demand reliability analysis based on IEC61508 standards for safety-critical systems using component field-failure data is carried out and the drop-weight configuration essential to meet the human-rated safety integrity level 3 during all stages of the subsea mission is identified for the deep-ocean human scientific submersible Matsya6000, based on which a mission abort protocol is evolved.
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http://dx.doi.org/10.1038/s41598-024-70158-3 | DOI Listing |
Healthcare (Basel)
June 2025
Institute for Population and Precision Health, The University of Chicago, Chicago, IL 60637, USA.
Background: Breast cancer poses a significant health challenge in Bangladesh, where limited screening and unique reproductive patterns contribute to delayed diagnoses and subtype-specific disparities. While reproductive risk factors such as age at menarche, parity, and contraceptive use are well studied in high-income countries, their associations with hormone-receptor-positive (HR+) and triple-negative breast cancer (TNBC) remain underexplored in low-resource settings.
Methods: A case-control study was conducted at the National Institute of Cancer Research and Hospital (NICRH) including 486 histopathologically confirmed breast cancer cases (246 HR+, 240 TNBC) and 443 cancer-free controls.
PLoS One
June 2025
College of Public Health, OSU, Columbus, Ohio, United States of America.
Objectives: Crisis pregnancy centers (CPCs) typically hold missions of preventing abortion, opposing contraception, and promoting abstinence outside of marriage. They often lack transparency about their services, posing as medical facilities or even as abortion clinics. Given the lack of evidence on the extent to which people use crisis pregnancy centers, we sought to quantify the prevalence of ever attendance at a CPC among adult, reproductive-aged women from Survey of Women data from four states.
View Article and Find Full Text PDFRisk Anal
July 2025
School of Management, Beijing Institute of Technology, Beijing, China.
This study explores the risk management challenges associated with safety-critical systems required to execute specific missions. The working component experiences degradation governed by a continuous-time discrete-state Markov chain, whose failure leads to an immediate system breakdown and safety losses. To enhance system survivability, a limited number of identical spares are available for online replacement throughout the mission.
View Article and Find Full Text PDFGynecol Oncol Rep
December 2024
Duke University Hospital, DUMC 3079, Durham, NC 27710, United States.
JMIR Public Health Surveill
November 2024
Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, United States.
Background: Crisis pregnancy centers (CPCs) are religious nonprofit organizations with a primary mission of diverting people from having abortions. One CPC tactic has been to locate near abortion facilities. Despite medical groups' warnings that CPCs do not adhere to medical and ethical standards and pose risks, government support for CPCs has significantly increased.
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