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Non-exudative choroidal and/or macular neovascularizations (NV) represent nowadays a common finding in different retinal disorders. The introduction of non-invasive techniques such as structural optical coherence tomography (OCT) and OCT angiography (OCTA) allowed for easy detection and follow-up of non-exudative NVs. Recognized as a distinct entity, these lesions demonstrate a high variability in terms of pathophysiology, morphology, and prognostic implications. In the absence of a consensus regarding correct classification of subtypes of non-exudative NVs, accurate management through strict follow-up strategies and prompt treatment is required. In this review we offer a comprehensive overview of the non-exudative NV spectrum in various retinal diseases aiming to provide a deeper insight into this clinical entity.
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http://dx.doi.org/10.1177/11206721241275206 | DOI Listing |
Retin Cases Brief Rep
August 2025
Doheny Eye Institute, Pasadena, CA, USA.
Purpose: To describe the multimodal imaging features of intraretinal sclero-choroidal vessels (ISCVs) in eyes with severe chorioretinal thinning.
Methods: A retrospective observational case series. We examined 6 eyes of 6 patients with advanced chorioretinal thinning presenting to the Doheny UCLA Eye Centers (pathologic myopia with posterior staphyloma, iatrogenic staphyloma, chronic anti-VEGF exposure, or non-myopic macular atrophy).
J Neurointerv Surg
August 2025
Buenos Aires Macula Clinical Research, Buenos Aires, Argentina.
Background: There is increasing evidence that vascular disease and chronic perfusion deficits play a role in the progression of age-related macular degeneration (AMD). This controlled clinical study evaluated the safety and feasibility of treating patients with late-stage AMD and associated geographic atrophy (GA). In addition, exploratory endpoints evaluated the potential to disrupt the disease process and initiate functional changes.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
August 2025
School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Purpose: The purpose of this study was to analyze the prognostic significance of double-layer sign (DLS) in eyes with foveal-sparing geographic atrophy (GA) secondary to age-related macular degeneration.
Methods: This retrospective, observational cohort study analyzed 46 eyes (46 patients) with foveal sparing GA and associated DLS, using fundus autofluorescence (FAF), near-infrared reflectance (NIR), optical coherence tomography (OCT), and OCT angiography (OCTA). DLS was defined based on OCTA findings as either thick basal laminar deposits (BLamD) or non-exudative macular neovascularization (NE-MNV).
Exp Eye Res
October 2025
Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, 21287, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21287, USA. Electronic address:
Choroidal neovascularization (CNV) has been associated with a wide variety of chorioretinal disorders, which can cause vascular leakage, bleeding, and scar formation, leading to significant vision loss. The effective and precise detection of CNV is essential for optimal disease management. A classification system has been devised to categorize neovascularization according to its anatomical location.
View Article and Find Full Text PDFSci Rep
July 2025
Karl Landsteiner Institute for Retinal Research and Imaging, Juchgasse 25, 1030, Vienna, Austria.
The short-term conversion rate of a non-exudative macular neovascularization (ne-MNV) to an exudative stage in age-related macular degeneration (AMD) was evaluated in a single-center, retrospective case control study and associated imaging characteristics described, using multimodal imaging. A total of 241 Caucasian patients with unilateral, treatment-naive exudative neovascular AMD were screened for the presence of a ne-MNV in the fellow eye between March 2016 and May 2022. Eyes with a confirmed ne-MNV on indocyanine green angiography and/or optical coherence tomography angiography (OCTA) were monitored using structural OCT for signs of exudation.
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