Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00277-024-05935-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mob-Marly: A Latin American experience in hematopoietic stem cell mobilization for autologous transplantation.
Transfus Apher Sci
August 2025
Apheresis and Cellular Therapy Unit, Department of Hemotherapy and Hemostasis, ICAMS, Hospital Clínic, IDIPAPS, UB, Barcelona, Spain.
Background: Hematopoietic stem cell (HSC) mobilization is a critical step in autologous transplantation for patients with multiple myeloma and lymphoma. While several risk factors for mobilization failure have been identified, real-world data from Latin America remain limited. This study aimed to describe mobilization outcomes and associated factors in a transplant center in Colombia.
View Article and Find Full Text PDFThe Impact of Anti-CD38 Monoclonal Antibody Therapy on Stem-Cell Mobilization Yields in Patients with Newly Diagnosed Multiple Myeloma (NDMM) Referred from Community and Academic Oncology Practices: Single Center, Real World Data 2021-2024.
Transplant Cell Ther
August 2025
Division of Blood and Marrow Transplant and Cellular Therapy, Stanford University School of Medicine, Stanford, CA. Electronic address:
Background: Autologous stem cell transplantation (ASCT) remains a standard component of frontline therapy for transplant-eligible patients with newly diagnosed multiple myeloma (NDMM). CD38 monoclonal antibodies (mAbs), such as daratumumab and isatuximab, have been incorporated into induction regimens and are associated with deeper responses. However, their impact on hematopoietic stem cell mobilization is unclear, particularly in real-world practice.
View Article and Find Full Text PDFA phase 2 trial of CXCR4 antagonism and PD1 inhibition in metastatic pancreatic adenocarcinoma reveals recruitment of T cells but also immunosuppressive macrophages.
Oncoimmunology
December 2025
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense stroma and myeloid-rich microenvironment that confer resistance to immunotherapies. Previous studies demonstrated that disrupting the immune-stroma CXCR4-CXCL12 axis facilitates T cell recruitment and mobility to collaborate with anti-PD1/PD-L1 therapy. We sought to test the clinical viability of this immunotherapeutic strategy.
View Article and Find Full Text PDFCXCR4-Mediated Chemokine Signaling Orchestrates the Progression of Conjunctival Melanocytic Lesions.
Invest Ophthalmol Vis Sci
August 2025
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Purpose: The biological and microenvironmental differences between benign and malignant conjunctival melanocytic lesions remain poorly understood. This study aims to characterize their microenvironment and reveal the role of chemokine signaling in lesion progression.
Methods: Bulk RNA sequencing and single-cell RNA sequencing were used to delineate the microenvironment of conjunctival melanocytic lesions and identify divergent molecular pathways.
Efficacy and safety of etoposide + cytarabine + pegfilgrastim mobilization regimen versus G-CSF mobilization regimen alone for hematopoietic stem cell mobilization in patients with multiple myeloma and lymphoma.
Cytotherapy
August 2025
Department of Hematology, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China; Institute of Hematology, Ningbo University, Ningbo, Zhejiang, China. Electronic address:
Background: Even with the tremendous progress made in treating multiple myeloma and lymphoma, autologous hematopoietic stem cell transplantation (ASCT) after high-dose chemotherapy is still an essential part of treatment. The mobilization of a sufficient number of high-quality peripheral blood stem cells (PBSC) is the main factor influencing the success of ASCT. However, further research is still needed to determine the best approach for hematopoietic stem cell mobilization.
View Article and Find Full Text PDF