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This study explores a retrospective non-targeted analysis (NTA), based on Ultra High-Performance Liquid Chromatography coupled to High-Resolution Mass Spectrometry (UHPLC-HRMS), to assess hidden chemicals of emerging concern (CECs) in marine model organisms. Conventional ecotoxicological studies do not include evaluating the natural habitats of the collected organisms, missing the possibility of highlighting unexpected pollutants, and thus compromising the correctness and reliability of the experimental results. In this paper we reprocessed samples previously collected from the Venice Lagoon for ecotoxicological studies and used for targeted analysis of three bisphenols-related compounds (i.e. BPS, BPF and BPAF) on seawater and specimens of the clam Ruditapes philippinarum. Results from the validation were the following: accuracy, expressed as percentage recoveries (R%), in the range 80%
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http://dx.doi.org/10.1016/j.chemosphere.2024.142994 DOI Listing Publication Analysis
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Ecotoxicol Environ Saf
September 2025
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua West Road, Jinan, Shandong 250012, China; Shandong Key Laboratory of Reproductive Health and Birth Defects Prevention and Control, China. Electronic address:
Di-isobutyl phthalate (DiBP), a member of the phthalate esters, is frequently used in manufacturing consumer and industrial products as plasticizer to improve durability and flexibility. Despite much research, little is known about the direct mechanisms by which DiBP harms the male reproductive system. In the present study, a male ICR mice model was developed to investigate the reproductive effect and mechanism of DiBP exposure, followed by transcriptomics, non-targeted metabolome, and 16S rDNA sequencing accordingly.
View Article and Find Full Text PDFFood Res Int
November 2025
SKL of Marine Food Processing & Safety Control, School of Food Science and Technology, Dalian Polytechnic University, Dalian, Liaoning 116034, China. Electronic address:
Fungal toxin contamination presents significant hazards to agroecosystems and food safety. Penicillium expansum (P. expansum) emerges as a primary threat, damaging sweet cherries through spoilage and generating the hazardous mycotoxin patulin (PAT).
View Article and Find Full Text PDFEnviron Res
September 2025
Department of Analytical and Applied Chemistry, School of Engineering, Institut Químic de Sarrià-Universitat Ramon Llull (IQS-URL), Via Augusta 390, Barcelona, 08017, Spain. Electronic address:
Glyphosate (GLY) is the most widely used herbicide globally and is frequently detected in aquatic environments at low concentrations, raising concerns about its potential long-term effects on non-target organisms. However, the systemic metabolic disruptions of chronic GLY exposure in aquatic vertebrates remain poorly understood, especially at environmentally relevant concentrations. This study investigates the metabolic disruptions of GLY exposure in zebrafish (D.
View Article and Find Full Text PDFFood Sci Biotechnol
October 2025
College of Food Science and Engineering, Jilin University, Changchun, 130062 Jilin China.
Unlabelled: Lactic acid bacteria (LAB) fermentation has been shown to improve the nutritional and functional activity of grains. The aim of this study was to investigate the changes in physicochemical properties, antioxidant activity, hypoglycaemic activity and metabolites of maize juice after fermentation with two species of Lactobacillus and . The non-targeted metabolomics analysis based on UHPLC-Q-TOF-MS metabolomics method was performed to reveal the metabolic mechanism of corn juice.
View Article and Find Full Text PDFIndian J Endocrinol Metab
August 2025
Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.
Metabolomics is a type of laboratory science used to understand the cellular and metabolic defects in any disease process. It comprehensively identifies endogenous and exogenous low-molecular-weight (<1 kDa) molecules or metabolites in a high-throughput manner. Mass spectrometry-based methods are used for metabolomics which can be targeted and non-targeted.
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