Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Elevated renin has been shown to predict poor response to standard vasoactive therapies and is associated with poor outcomes in adults. Similarly, elevated renin was associated with mortality in children with septic shock. Renin concentration profiles after pediatric cardiac surgery are unknown. The purpose of this study was to characterize renin kinetics after pediatric cardiac surgery.
Methods: Single-center retrospective study of infants who underwent cardiac surgery with cardiopulmonary bypass (CPB) utilizing serum samples obtained in the perioperative period to measure plasma renin concentrations (pg/mL). Time points included pre-bypass and 1, 4, and 24 h after initiation of CPB.
Results: Fifty patients (65% male) with a median age 5 months (interquartile range (IQR) 3.5, 6.5) were included. Renin concentrations peaked 4 h after CPB. There was a significant difference in preoperative and 4 h post-CPB renin concentration (4 h post-CPB vs preoperative: mean difference 100.6, 95% confidence interval (CI) 48.9-152.4, < .001). Median renin concentration at 24 h after CPB was lower than the preoperative baseline.
Conclusions: We describe renin kinetics in infants after CPB. Future studies based on these data can now be performed to evaluate the associations of elevated renin concentrations with adverse outcomes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639413 | PMC |
| http://dx.doi.org/10.1177/08850666241268655 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intrarenal Generation of Aldosterone Contributes to Ischemia-Induced Hypertension and Nephropathy in Mice.
bioRxiv
August 2025
Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, 84132, USA.
Background: The past few years have witnessed a significant advancement in aldosterone (Aldo)-targeted therapies for the management of treatment-resistant hypertension and chronic kidney disease, which often exist in tandem. While Aldo is believed to predominantly originate from the adrenal glands, this study provides evidence to support the involvement of intrarenal Aldo biosynthesis in the pathogenesis of ischemic nephropathy and hypertension in a two-kidney, one-clip (2K1C) model.
Methods: We generated inducible renal tubule-specific deletion of C11B2 (RT C11B2 KO) and characterized the phenotype during the 2K1C procedure.
Bronchopulmonary dysplasia induced by hyperoxia attenuated by A GLP-1 analog, Liraglutide, by regulating the ACE-2/Ang(1-7)/Mas receptor pathway.
Pediatr Res
September 2025
Department of Pediatrics, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Background: Glucagon-like peptide-1 (GLP-1) shows promise for treating hyperoxia-induced bronchopulmonary dysplasia (BPD), but its mechanisms remain unclear. This study investigated the effects and potential mechanisms of GLP-1 using a hyperoxia-induced neonatal BPD mouse model.
Methods: Sprague-Dawley (SD) newborn rats were randomly assigned to four groups: control, hyperoxia, hyperoxia+Liraglutide, and hyperoxia+Liraglutide+A779.
Weight loss following gastric bypass increases aldosterone reactivity to orthostatic stress in patients with obesity.
Blood Press
September 2025
Service of nephrology and hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Background: Weight loss after gastric bypass is associated with blood pressure reduction. However, the precise role of the sympathetic nervous system and renin-angiotensin-aldosterone system in this reduction remains unclear. We investigated the effect of RYGB-induced weight loss on the hemodynamic, hormonal, and renal responses to an orthostatic stress induced by lower body negative pressure (LBNP).
View Article and Find Full Text PDFCirculating angiotensin-converting enzyme 2 concentration is associated with acute kidney injury and mortality in sepsis.
PLoS One
August 2025
Institute of Clinical Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan.
Background: Beyond the well-established classical renin-angiotensin system (RAS), emerging evidence highlights the critical role of the non-classical RAS, specifically the Angiotensin (1-7)/ACE2/Mas axis. As the key enzyme converting Angiotensin II into Angiotensin (1-7), angiotensin-converting enzyme 2 (ACE2) exerts cardioprotective and anti-inflammatory effects, showing potential therapeutic value in critical care. This study investigates the association between circulating ACE2 levels and clinical outcomes in sepsis, offering insights into its role and potential for predicting sepsis outcomes.
View Article and Find Full Text PDFOptimal Maintenance Strategy for Patients with Improved Left Ventricular Function Following Sacubitril/Valsartan Therapy.
Medicina (Kaunas)
August 2025
Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.
: Optimal pharmacological treatment following left ventricular ejection fraction (LVEF) improvement remains largely unknown. This study compared the clinical outcomes of patients with heart failure (HF) with improved EF (HFimpEF) based on the maintenance of sacubitril/valsartan (S/V) or transition to a renin-angiotensin system blocker (RASB). : A total of 354 patients with recovered LVEF of at least 40% after S/V treatment from a single center were retrospectively analyzed.
View Article and Find Full Text PDF