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http://dx.doi.org/10.1007/s00270-024-03821-x | DOI Listing |
Radiol Imaging Cancer
September 2025
Department of Radiation Oncology, Cancer Center, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road, Guangzhou, China 510080.
Purpose To develop and test a machine learning (ML)-based model that integrates preoperative variables for prediction of advanced-stage progression (ASP) after transarterial chemoembolization (TACE). Materials and Methods This multicenter retrospective study (ResearchRegistry.com identifier no.
View Article and Find Full Text PDFJ Immunother Cancer
August 2025
Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Anti-programed cell death protein-1 (PD-1) and anti-programmed cell death 1 ligand 1 (PD-L1) antibodies combined with anti-vascular endothelial growth factor (VEGF) or anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies are now standard therapeutic options for patients with treatment-naïve, advanced stage, hepatocellular carcinoma. Given the observed efficacy in the advanced setting, the unmet need for therapies for intermediate stage liver cancer, and compelling preclinical rationale for combination with liver-directed therapies, such as transarterial chemoembolization, immunotherapies have quickly moved into earlier stages of the disease. Several phase 1/2 clinical trials have collectively verified the safety of immune checkpoint blockade with regional therapy for intermediate stage, liver-limited, hepatocellular carcinoma.
View Article and Find Full Text PDFFront Pediatr
July 2025
Department of Pediatric Surgery & Vascular Anomalies, Xi'an International Medical Center Hospital, Xi'an, China.
Hepatobiliary Surg Nutr
April 2025
Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.
Cardiovasc Intervent Radiol
April 2025
Department of Radiology, The University of Alabama at Birmingham, Birmingham, USA.