Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10753-024-02111-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The assessment of the fibrinogen-to-platelet ratio for predicting mortality of COVID-19 in non-diabetic subjects.
Int J Environ Health Res
September 2025
Department of Research, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Instituto Mexicano del Seguro Social (IMSS), Veracruz, Mexico.
Little is known about the biomarkers of mortality in SARS-CoV-2-infected patients without a previous diagnosis of diabetes. Thus, this study aimed to assess the fibrinogen-to-platelet ratio (FPR) and compare its predictive value with the main biomarkers for COVID-19 mortality, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), leukocyte glucose index (LGI), and lactate dehydrogenase (LDH)/lymphocyte ratio. This retrospective cohort study in a population of Mexico included 70 non-diabetic patients with COVID-19 from 1 May 2020 to 30 September 2020.
View Article and Find Full Text PDFReassessment of antibody-based detection of the murine T cell GLP-1 receptor.
Cell Metab
September 2025
Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON, Canada. Electronic address:
Glucagon-like peptide 1 receptor (GLP-1R) agonists exhibit anti-inflammatory actions, yet the importance of direct immune cell GLP-1R signaling remains uncertain. Although T cells respond to GLP-1, low receptor abundance and suboptimal antisera complicate efforts to characterize immune cell GLP-1R signaling. Here, we evaluate three frequently utilized GLP-1R antibodies, revealing that one of several antibodies, AGR-021, lack ideal specificity for detecting the GLP-1R in mice.
View Article and Find Full Text PDFMaxacalcitol alleviates diabetes-associated periodontitis in male mice by restoring Treg/Th17 balance via SOCE-mediated mitochondrial dysfunction.
J Periodontol
September 2025
Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Ce
Background: CD4 T lymphocytes play a central role in the pathogenesis of periodontitis, with the Treg/Th17 (regulatory T cell/T helper 17 cell) imbalance closely linked to diabetes-associated periodontitis (DPD). Maxacalcitol (OCT), an analog of active vitamin D, has therapeutic effects on diseases involving Treg/Th17 imbalance. This study aimed to determine whether OCT improved DPD by restoring the Treg/Th17 imbalance via store-operated Ca entry (SOCE)-mediated mitochondrial dysfunction.
View Article and Find Full Text PDFT lymphocyte subsets and mitochondrial index predict outcomes in advanced non small cell lung cancer therapy.
Sci Rep
August 2025
Department of Respiration, Jinhua Municipal Central Hospital, Jinhua, 321000, China.
Currently, accessible objective indicators for predicting the prognosis and treatment outcomes of non-small cell lung cancer (NSCLC) are lacking. This study investigates the potential of T lymphocyte subsets and mitochondrial biomarkers as predictors of metastasis and evaluators of therapy response in advanced NSCLC. We analyzed clinical data from 24 advanced NSCLC patients, including T-cell counts and mitochondrial mass (MM)/membrane potential (MMP) measurements.
View Article and Find Full Text PDFGD2T cells as a platform for single-dose and long-term delivery of biologics.
Nat Commun
August 2025
State Key Laboratory of Molecular Oncology, Tsinghua University, Beijing, China.
The efficacy of biologics, such as peptide and protein drugs, is often limited by their short half-lives in vivo, necessitating repeated infusions to maintain therapeutic effects. Here, we demonstrate that long-lived CAR T cells can be leveraged as a versatile platform for long-term delivery of biologics. Our recent findings show that the depletion of BCOR and ZC3H12A induces GD2 CAR T cells into an immortal-like and functional state, which we have termed GD2T cells.
View Article and Find Full Text PDF