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Article Abstract
Background: Delayed cord clamping (DCC) occurs in most preterm births.
Objective: Evaluate the association of DCC with acute kidney injury (AKI) and two-year kidney outcomes.
Methods: Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial of neonates born 24 to 27 weeks' gestation. AKI and two year kidney outcomes were compared in neonates with DCC (≥30 seconds after delivery) to those with early cord clamping (ECC) (<30 seconds after delivery).
Results: The incidence and severity of AKI did not differ between the DCC and ECC groups (aOR 1.17 [95%CI 0.76-1.80]). At two years corrected age, DCC was associated with a 4.5-fold times increased adjusted odds of eGFR <90 mL/min/1.73m. No significant associations were noted between DCC and albuminuria or elevated BP.
Conclusions: DCC was not associated with decreased neonatal AKI, but was associated with higher adjusted odds of eGFR <90 mL/min/1.73m at two years.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11276018 | PMC |
| http://dx.doi.org/10.21203/rs.3.rs-4631779/v1 | DOI Listing |
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