Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Backgrounds: The titanium-aluminum-vanadium alloy (Ti-6Al-4V) is frequently used in implantology due to its biocompatibility. The use of 3D printing enables the mechanical modification of implant structures and the adaptation of their shape to the specific needs of individual patients.
Methods: The titanium alloy plates were designed using the 3D CAD method and printed using a 3D SLM printer. Qualitative tests were performed on the material surface using a microcomputed tomography scanner. The cytotoxicity of the modular titanium plates was investigated using the MTT assay on the L929 cell line and in direct contact with Balb/3T3 cells. Cell adhesion to the material surface was evaluated with hFOB1.19 human osteoblasts. Microbial biofilm formation was investigated on strains of , , and using the TTC test and scanning electron microscopy (SEM).
Results: The surface analysis showed the hydrophobic nature of the implant. The study showed that the titanium plates had no cytotoxic properties. In addition, the material surface showed favorable properties for osteoblast adhesion. Among the microorganisms tested, the strains of and showed the highest adhesion capacity to the plate surface, while the fungus C. albicans showed the lowest adhesion capacity.
Conclusions: The manufactured modular plates have properties that are advantageous for the implantation and reduction in selected forms of microbial biofilm. Three-dimensional-printed modular titanium plates were investigated in this study and revealed the potential clinical application of this type of materials, regarding lack of cytotoxicity, high adhesion properties for osteoblasts and reduction in biofilm formation. The 3D CAD method allows us to personalise the shape of implants for individual patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11274415 | PMC |
| http://dx.doi.org/10.3390/biomedicines12071466 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biologically Active Implants Prevent Mortality in a Mouse Sepsis Model.
Adv Healthc Mater
August 2025
School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
Implant-associated infections remain a significant complication in medicine. often leading to chronic infection, tissue damage, or implant failure. To address this, this work develops a modular, triple-action titanium implant that integrates bacterial repellency, bactericidal activity, and enhanced tissue integration.
View Article and Find Full Text PDFMatrix Wave System for Mandibulo-Maxillary Fixation-Just Another Variation on the MMF Theme? Part I: A Review on the Provenance, Evolution and Properties of the System.
Craniomaxillofac Trauma Reconstr
September 2025
Division of Oral and Maxillofacial Surgery, Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York, NY 10003, USA;
Study Design: The advent of the Matrix Wave System (Depuy-Synthes)-a bone-anchored Mandibulo-Maxillary Fixation (MMF) System-merits closer consideration because of its peculiarities.
Objective: This study alludes to two preliminary stages in the evolution of the Matrix Wave MMF System and details its technical and functional features.
Results: The Matrix Wave System (MWS) is characterized by a smoothed square-shaped Titanium rod profile with a flexible undulating geometry distinct from the flat plate framework in Erich arch bars.
Establishment of a clinically relevant beagle model for periprosthetic joint infection with 3D-printed prostheses and multimodal evaluation.
J Orthop Translat
July 2025
Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
Objective: Periprosthetic joint infection (PJI) poses significant challenges to arthroplasty outcomes, necessitating translational animal models for pathogenesis studies and therapeutic development. This study aimed to establish a standardized Beagle PJI model by integrating species-specific 3D-printed femoral prostheses with quantitative bacterial inoculation, while evaluating the dose-dependent effects of () on infection progression.
Methods: Two titanium alloy prostheses were designed using CT-based anatomical data: BFP-C (canine-optimized) and BFP-H (human-derived).
Ligand-Mediated Proton-Coupled Electron Injection into Reactive Cores of Soluble Macroanion-Like Complexes of Titanium Dioxide.
J Am Chem Soc
July 2025
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
Although widely utilized as reactive components of devices and functional materials, the harnessing of metal-oxide nanocrystals (NCs) as ligand-tunable reaction centers of soluble catalysts remains an ongoing challenge. We now report that readily modifiable, oxidatively inert polyoxometalate (POM) ligands amplify and rationally control rates of photocatalytic H evolution by anatase-TiO NCs. This was achieved using a series of four POM-derived oxo-donor ligands, [(XWO)Ti-O], X = Al, Si, P, and [(PWO)Ti-O] (written here as oxo-anion donors) coordinated via bridging-oxo linkages to Ti atoms at the surfaces of 7 ± 1.
View Article and Find Full Text PDFMagnetic-enzymatic synergy driven photoelectrochemical aptasensor on a microfluidic chip for sub-pM kanamycin detection.
Lab Chip
July 2025
School of Environmental and Chemical Engineering & Shanghai Key Laboratory of Materials Protection and Adv. Mater. in Electric Power, Shanghai University of Electric Power, Shanghai 200090, China.
The escalating global concern over antibiotic contamination in food chains and aquatic ecosystems demands innovative solutions for rapid, on-site monitoring of residual drugs. This study presents an autonomous microfluidic photoelectrochemical (PEC) biosensing platform that synergizes magnetic purification, enzymatic amplification, and nanohybrid-enhanced signal transduction for field-deployable, ultrasensitive kanamycin (KAN) detection. The system integrates three functional layers: aptamer-functionalized magnetic beads (MBs) for selective KAN isolation, alkaline phosphatase (ALP)-catalyzed hydrolysis of L-ascorbic acid 2-phosphate (AAP) to generate electron-donating ascorbic acid (AA), and a TiO/NbC/carbon nitride (CN) photoanode with a type-II heterojunction architecture for an amplified photocurrent response.
View Article and Find Full Text PDF