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http://dx.doi.org/10.1016/j.jdcr.2024.01.038 | DOI Listing |
Dermatol Surg
July 2025
Department of Dermatology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland.
Background: Eccrine porocarcinoma is a rare cutaneous adnexal malignancy. Factors associated with metastasis of porocarcinoma and evidence for the utility of sentinel lymph node biopsy are incomplete within the literature.
Objective: Determine prognostic factors that may guide the decision to pursue sentinel lymph node biopsy in patients with porocarcinoma.
Histopathology
September 2025
Department of Pathology, Centre Hospitalier Universitaire de Tours, Université de Tours, Tours, France.
Unlabelled: NUT carcinoma is a rare malignant neoplasm characterised by recurrent NUTM1 rearrangements, initially reported in the midline. Recently, 10 cases of cutaneous NUT carcinoma with adnexal differentiation harbouring BRD3::NUTM1, NSD3::NUTM1, BRD4::NUTM1 or BRD3::NUTM2B fusions have been reported. Accordingly, 'NUT adnexal carcinoma' (NAC) has been introduced as a provisional tumour entity to the fifth edition of the WHO Classification of Skin Tumours.
View Article and Find Full Text PDFBr J Dermatol
March 2025
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
We have comprehensively characterized the mutational landscape of eccrine poroma (EP) and eccrine porocarcinoma (EPC), uncovering novel molecular events and delineating different pathways of tumorigenesis underlying these tumours. EPs are driven largely by oncogenic fusion genes, whereas EPCs are driven largely by somatic mutations affecting various pathways, with a subset driven by fusion genes as the first oncogenic driver, and somatic mutations representing secondary events contributing to progression of the tumour. Fusion genes in EP predominantly involve , while those in EPC preferentially involve gene family members.
View Article and Find Full Text PDFHead Neck Pathol
October 2024
Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Squamous cell carcinoma (SCC) is one of the most common malignancies involving the parotid gland, but it has been recognized that the vast majority of parotid SCC represents metastases, especially from the ipsilateral facial skin. Bona fide primary SCC of the parotid is so rare that it is unclear whether it truly exists at all. We sought to molecularly characterize cases diagnosed as primary parotid gland SCC to see if they possess a unique genetic makeup.
View Article and Find Full Text PDF