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The pandemic marked the beginning of an era of dynamic and rapid changes in the diagnosis of respiratory infections. Herein we describe Legionnaires' disease trend in the years 2016-2023 in a large Italian hospital showing how improvements in diagnostic algorithms impact on its detection.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442907 | PMC |
http://dx.doi.org/10.1007/s44197-024-00276-8 | DOI Listing |
Microb Genom
September 2025
New Zealand Institute for Public Health and Forensic Science, Porirua, New Zealand.
is a pathogen of global health importance due to its role in causing Legionnaires' disease (LD), a severe form of community-acquired pneumonia. Throughout the USA and Europe, is often identified as the primary cause of LD, but in countries such as New Zealand and Australia, where testing for non- species is employed systematically, high rates of are reported. Development of genomic tools to track outbreaks and identify infection sources for has lagged behind that of .
View Article and Find Full Text PDFJ Infect Dis
September 2025
Institute for Biomedicine and Glycomics, Griffith University, Southport, QLD, Australia.
Background: In 2021-2022, Queensland, Australia observed an increase in Legionnaire's disease cases, predominantly due to Legionella longbeachae. This study assessed seroprevalence at time points 2016 and 2023, representing before and after the higher incidence and explored if demographic, environmental and geographical factors associated with legionellosis seroprevalence.
Methods: A total of 1001 human plasma samples (496 from 2016/505 from 2023) were analysed for the presence of Legionella antibodies (IgG) using indirect immunofluorescence assays.
Sci Adv
September 2025
Department of Biochemistry, University of Toronto, 661 University Ave., Toronto, Ontario M5G 1M1, Canada.
Host cells provide intracellular bacteria with protection from harsh environmental conditions and immune responses, but for many intracellular pathogens, this protection does not appear to be absolute as once thought. Bacteriophages that can kill bacteria inside host cells have been identified for pathogens including , , and species. Even in pathogens for which no stable phages have been isolated, such as , the presence of phage defense systems suggests phage susceptibility.
View Article and Find Full Text PDFJ Pharm Technol
August 2025
Division of Infectious Diseases, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
pneumonia is a significant cause of community-acquired pneumonia that often requires timely and effective treatment. While fluoroquinolones and macrolides are the recommended first-line therapies, doxycycline offers an alternative with favorable pharmacokinetics, safety, and minimal drug-drug interactions. We describe three hospitalized patients with pneumonia who received doxycycline monotherapy.
View Article and Find Full Text PDFFront Microbiol
August 2025
Laboratory of Veterinary Public Health, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
Background: , an intracellular pathogen responsible for the pneumonia-like Legionnaires' disease in humans, inhabits aquatic environments, including man-made water systems such as water fountains, foot spas, and tap water, and exists as part of biofilms or as a protozoan parasite. As a bacterivore, provides a favorable environment for to establish a replicative niche (-containing vacuole; LCV) under environmental stress. Conversely, the Ofk308 strain, isolated from an Ashiyu foot spa, has been found to be cytotoxic to the ciliate CU427.
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