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This study comprehensively explores the clinical characteristics, diagnostic approaches, and treatment methods for liver mucinous cystic neoplasms (MCN). A retrospective analysis was conducted on seven individuals diagnosed with MCN, admitted to the Fifth Medical Center of the PLA General Hospital between October 2016 and May 2023. Preoperative AFP was negative, while CA19-9 was elevated in two cases. Surgical resection was performed for all patients. The patients showed favorable postoperative recovery. Follow-up revealed an excellent overall survival rate, except for one case of invasive carcinoma resulting in tumor recurrence and metastasis 6 months after surgery. MCN poses a diagnostic challenge due to the absence of distinct clinical and radiological features, leading to potential misdiagnosis and inappropriate treatment. Patients with suspected liver cystic diseases should consider the possibility of MCN. Surgical resection has proven to be a practical approach with satisfactory therapeutic outcomes.
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http://dx.doi.org/10.1038/s41598-024-67320-2 | DOI Listing |
World J Clin Oncol
August 2025
General Surgery Unit I - Liver Service, Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy.
Mucinous cystic neoplasms of the liver (MCN-L) are rare cystic lesions characterized by mucin-producing epithelium and ovarian-like stroma. Although they constitute fewer than 5% of hepatic cystic lesions, MCN-L poses significant diagnostic challenges due to overlapping features with other cystic lesions and their potential for malignant transformation. Early recognition and definitive surgical intervention are therefore critical to ensure optimal patient outcomes.
View Article and Find Full Text PDFExp Ther Med
October 2025
Department of Gastroenterology, Xixi Hospital, Hangzhou, Zhejiang 310023, P.R. China.
Hepatic mucinous cystic neoplasms (MCN) are rare cystic tumors that are predominantly observed in females, with a low incidence rate in males. To date, few cases of aggressive MCN have been reported in male patients. The current study reports the case of a 74-year-old male patient who presented to Xixi Hospital with abdominal distension.
View Article and Find Full Text PDFBreast Cancer
September 2025
Division of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Background: Morphological features of tumors can reflect the biological behavior of breast carcinoma; however, a consensus macroscopic classification remains elusive. In this study, we aimed to elucidate the relationship between macroscopic morphology and biological behavior of breast carcinoma.
Methods: We evaluated 328 post-operative breast carcinomas, stratifying them by hormone receptor/human epidermal growth factor receptor 2 (HER2) status (luminal-like, luminal-HER2, HER2-positive [non-luminal], triple-negative), and morphological patterns.
Radiol Case Rep
November 2025
Department of Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.
Mature cystic teratomas (MCTs) are common ovarian neoplasms that rarely undergo malignant transformation, particularly in pediatric patients. We report a rare case of a 5-year-old girl presenting with abdominal distension and back pain, initially managed with incomplete excision of an ovarian mass without histopathological evaluation. Recurrence led to debulking surgery revealing a mixed germ cell tumor, and subsequent imaging identified a residual abdominopelvic mass with elevated alpha-fetoprotein levels.
View Article and Find Full Text PDFCancer Cell
August 2025
Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, M
To enable early detection of pancreatic cancer from precancerous lesions, we analyze proteins and glycoproteins from 64 intraductal papillary mucinous neoplasms (IPMNs), 55 cyst fluid samples, 104 pancreatic ductal adenocarcinomas (PDACs), and various types of normal samples using mass spectrometry. High-grade IPMNs show enrichment of glycosylation level and tumor progression pathways compared to low-grade lesions. High-grade IPMN associated proteins, such as PLOD3, IRS2, LGALS9, and Trop-2, are identified and validated using immunolabeling and laser microdissection.
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