Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: We previously showed that total tumor resection enhances metastatic growth in a syngeneic metastatic mouse model of neuroblastoma. In this study, we further investigated which surgical factors contributed most to metastatic growth.
Methods: Tumor cells derived from MYCN transgenic mice were subcutaneously injected into wild-type mice. Mice were randomly assigned to receive partial resection (PR group), subcutaneous implantation of a sponge (Sp group), or observation (Obs group). The lymph node metastasis volume and the frequency of lung metastasis were compared 14 days after assignment by measuring C-reactive protein (CRP) and interleukin-6 (IL-6) levels.
Results: The lymph node metastasis volume in the Sp group was larger than in the Obs group (148.4 [standard deviation {SD}: 209.5] vs. 10.2 [SD 12.8] mm). The frequency of lung metastasis was greater in the Sp group than in the PR group (11.9 [SD 12.2] vs. 6.6 [SD 4.0] counts/slide). The CRP level in the Sp group was higher than in the PR group (2.3 [SD 0.5] vs. 1.5 [SD 0.4] μg/mL), and the IL-6 level in the Sp group was higher than in the PR or Obs groups (28.4 [SD 34.5] vs. 12.4 [SD 19.0] vs. 5.4 [SD 8.1] pg/mL).
Conclusion: Metastatic growth may be enhanced by systemic inflammation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00383-024-05788-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Safety and Efficacy Assessment of Trastuzumab Emtansine in Indian Patients With Human Epidermal Growth Factor Receptor 2-Positive Unresectable Locally Advanced or Metastatic Breast Cancer Previously Treated With Trastuzumab and a Taxane: An Open-Label, Single-Arm, Phase IV Study.
Asia Pac J Clin Oncol
September 2025
Roche Products India Pvt. Ltd, Mumbai, India.
Introduction: Trastuzumab emtansine (T-DM1), an antibody-drug conjugate, targets tumor cells overexpressing human epidermal growth factor receptor 2 (HER2). This single-arm, phase IV study assessed the safety and efficacy of T-DM1 in Indian patients with HER2-positive, locally advanced, or metastatic breast cancer previously treated with trastuzumab and a taxane.
Methods: Patients received T-DM1 (3.
Case Report: Double trabecular metal cup without auxiliary screws for severe acetabular bone defects.
Front Surg
August 2025
Department of Orthopedics, The First Hospital of Jilin University, Changchun, Jilin, China.
Background: Acetabular reconstruction is often challenging in revision hip arthroplasty, especially in the face of moderate to severe acetabular bone deficiency. In some severe bone defects, double-metal tantalum cups can improve the contact area between bone and implants, increase the surface area for bone ingrowth, and better restore the anatomical position of the acetabulum. Furthermore, with a good press-fit, the auxiliary screw has a minimal effect on acetabular cup stability.
View Article and Find Full Text PDFTourism, Real Estate, and Urban Pressures: The case of Marsascala, Malta.
Open Res Eur
August 2025
Universidad de La Laguna, San Cristóbal de La Laguna, Canary Islands, Spain.
This paper examines the urban transformation of Marsascala, a coastal town in Malta, through the lens of tourism development and its social repercussions. Engaging with Young's (1983) model of touristization and landscape change, and drawing from qualitative interviews, field observations, orthophoto analysis, and secondary data, the study traces the town's evolution from a fishing village to a site of intensive tourism consolidation. Findings reveal how population growth-driven by tourism and foreign labour-has led to overdevelopment, infrastructural strain, and a declining quality of life.
View Article and Find Full Text PDFBeyond the First Year of Intravitreal Faricimab for Diabetic Macular Oedema: A Single-Centre Experience.
Cureus
August 2025
Ophthalmology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, GBR.
Objective To determine real-world clinical outcomes (including vision, anatomy and durability) of intravitreal faricimab (IVF) in year two (up to mean follow-up of 75 ± 15 weeks, range: 52-103 weeks) of treating diabetic macular oedema (DMO). Secondary objectives included assessing changes in diabetic retinopathy (DR) severity, the incidence of epiretinal proliferation (ERP)/epiretinal membrane (ERM), and safety. Methodology This is a single-centre retrospective observational study.
View Article and Find Full Text PDFFirst-Line Aumolertinib in -Mutant Advanced Non-Small Cell Lung Cancer: A Multicenter Real-World Retrospective Study with a Four-Year Follow-Up.
Oncol Res
September 2025
Department of Oncology, Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
Background: The use of third-generation different tyrosine kinase inhibitors (TKIs) is considered the most effective option for treating advanced non-small cell lung cancer (aNSCLC) with epidermal growth factor receptor (EGFR) mutations. However, there is limited information on the efficacy and safety of aumolertinib in patients remains these cases.
Methods: The clinical records of patients receiving aumolertinib as first-line therapy across four hospitals in the Guangxi Zhuang Autonomous Region from April 2020 to December 2021 were retrospectively analyzed, using progression-free survival (PFS) as the primary endpoint and overall survival (OS) representing the secondary endpoint.