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Visible-light optical coherence tomography (vis-OCT) is a novel noninvasive retinal imaging system that offers improved resolution compared to conventional near-infrared (NIR) OCT systems. Here, we utilized vis-OCT to produce fibergrams (vis-OCTF) for the first time in human patients, enabling visualization and precise quantification of hyperreflective dots in the central fovea in two patients. We also directly compare the imaging qualities of conventional vis-OCT and NIR-OCT. Vis-OCT generated a 3 × 3 mm image with an impressive axial resolution of 1.3 m, whereas NIR-OCT produced an image with a larger field of view (FOV) (9 × 9 mm) but a lower resolution of 7.0 m. Moreover, vis-OCTF unveiled clear images of hyperreflective dots in the fovea of both patients, which were not discernible in the NIR-OCT images. Foveal dots have often been linked to several age-related and pathological conditions. The high-resolution images generated by vis-OCTF enable more precise characterization of changes in retinal sublayers within the central fovea.
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http://dx.doi.org/10.1155/2024/5823455 | DOI Listing |
Ocul Immunol Inflamm
August 2025
Department of Ophthalmology, Charles Nicolle Hospital, Rouen, France.
Purpose: To describe a clinicopathological correlation between optical coherence tomography (OCT) and serum immunofluorescence in a case of cancer associated retinopathy (CAR) masquerading as white dot syndrome.
Methods: A retrospective case report.
Results: A 72-year-old man with a visual acuity of 20/20 in both eyes presented with white dots in the left eye.
Ophthalmol Retina
July 2025
Department of Ophthalmology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Purpose: To examine near infrared reflectance (NIR) imaging in acute syphilitic outer retinitis.
Design: Retrospective case series.
Subjects: Patients diagnosed with ocular syphilis from 2015 to 2024 at Wake Forest Baptist Hospital.
Ophthalmol Ther
August 2025
Programme for Ocular Inflammation and Infection Translational Research, Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
Introduction: The use of optical coherence tomography (OCT) as a potential tool for the measurement of vitreous inflammation has been previously described as a more objective and reproducible method when compared to historically known subjective scales. In this study, our objective is to evaluate OCT's ability to characterize vitreous hyperreflective dots (VHDs) across eyes with varying conditions, including healthy controls, vitreous degenerations, intraocular inflammation, and others.
Methods: We utilized a purpose built semiautomated software comprising an image binarization tool to segment OCT scans of 61 eyes, comprising 15 eyes with vitreous degenerations, 20 uveitic eyes, 17 healthy controls, and 9 with other eye conditions.
Int J Retina Vitreous
June 2025
Orbit Ophthalmo Learning, Salvador, Brazil.
Background: The inner plexiform layer (IPL) of the retina plays a key role in visual processing, consisting of five stratified sub-bands (S1-S5) that segregate ON and OFF visual pathways. Until now, resolving these IPL sub-layers was only possible with experimental high-resolution (HR-OCT) or visible-light OCT (VIS-OCT), which remain inaccessible for clinical use. This study provides the first demonstration that IPL stratification can be visualized using commercially available spectral-domain OCT (SD-OCT) with optimized imaging and grayscale inversion.
View Article and Find Full Text PDFJ Ophthalmol
May 2025
School of Optometry and Vision Science, The University of Auckland, Auckland, New Zealand.
Abnormalities in the retina have a profound impact on vision, and accurate diagnosis and monitoring are essential for effective clinical management. Retinal hyperreflective foci (HRF), lesions, or dots, identified using optical coherence tomography (OCT), are observed in both animals and humans and have been associated with several ocular conditions, including diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinal vascular diseases. To evaluate the relevance of retinal HRF, we conducted a comprehensive scoping review of the literature published up to July 2024 including in the discussion key papers that emerged in 2025.
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