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Systemic Lupus Erythematosus (SLE) is a chronic, autoimmune and multisystemic rheumatic disease. Patients with SLE have decreased functional and aerobic capacity, as well as increased prevalence of Cardiovascular Diseases (CVD), which are the primary causes of morbimortality in this condition. Dietary intake and physical activity are well-known modifiable cardiovascular risk factors. The aim of this study is to describe food consumption, sedentary behavior, physical activity level, and functional and aerobic capacity in a sample of SLE patients with high cardiovascular risk. This was a cross-sectional study in which patients were assessed for (i) Demographic, anthropometric, and disease-related parameters; (ii) Food consumption; (iii) Physical activity level and sedentary behavior; (iv) Functional and aerobic capacity. Patients averaged 41.7 ± 9 years, and most were classified as overweight/obese (87%). Average macronutrient intake was within recommendations; however, fiber (16 ± 9g) and calcium (391 ± 217 mg) intakes were below, and sodium intake (2.9 ± 1.3 mg) was above recommendations. Besides, food consumption assessed by the Nova system showed a predominance of unprocessed foods (43.8 ± 14.0%TEI), although ultraprocessed food intake (20.0 ± 13.9%TEI) was slightly higher than that seen in the Brazilian population. Patients also exhibited high sedentary behavior (8.2 ± 2.2h) and only eighteen participants reached the minimum recommended amount of moderate-to-vigorous physical activity. Overall, patients had a low functional and aerobic capacity compared to the general population. Data from this study may help design dedicated clinical trials aiming to investigate the effects of lifestyle intervention to mitigate CVD in SLE.
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http://dx.doi.org/10.1016/j.clinsp.2024.100418 | DOI Listing |
J Biomech
August 2025
Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA; Department of Mechanical Engineering & Materials Science, Pratt School of Engineering, Duke University, Durham,
While knee osteoarthritis (OA) is a leading cause of disability in the United States, OA within the patellofemoral joint is understudied compared to the tibiofemoral joint. Mechanical alterations to cartilage may be among the first changes indicative of early OA. MR-based protocols have probed patellar cartilage mechanical function by measuring deformations in response to exercise.
View Article and Find Full Text PDFAnim Reprod Sci
September 2025
Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Al. Mickiewicza 24/28, Krakow 30-059, Poland.
Irisin, a myokine/adipokine released during physical activity, has attracted attention for its regulatory effects on various physiological processes, including metabolism and reproduction. This study was performed to investigate the presence of fibronectin type III domain-containing protein 5 (FNDC5) in chicken granulosa cells (GCs) using immunocytochemistry and to assess the effect of irisin, the extracellular fragment of FNDC5, on these cells, which play a crucial role in progesterone (P4) production and follicle maturation. We measured cell viability, mRNA expression of the luteinising hormone receptor (LHR), the expression of steroidogenic genes (StAR, CYP11A1, and 3BHSD), and P4 secretion in GCs of chicken ovarian follicles.
View Article and Find Full Text PDFJ Physiol
September 2025
Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, USA.
Cognitive decline and physical impairment are often linked with ageing, contributing to declines in health span and loss of independence in older adults. Pathological cognitive decline with age is largely considered to be a brain-centric challenge. However, recent findings have begun to challenge this paradigm as the health of peripheral systems, namely skeletal muscle, predict cognitive decline associated with Alzheimer's disease (AD).
View Article and Find Full Text PDFJ Physiol
September 2025
Institue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.
Some patients with heart failure with preserved ejection fraction (HFpEF) have demonstrated evidence of exercise-induced arterial hypoxaemia (EIAH). However, EIAH was not quantified using , , and measurements as previously conducted in healthy adults nor was EIAH quantified alongside simultaneous measurements of pulmonary vascular pressures, cardiorespiratory responses, or dyspnoea on exertion (DOE) in these patients. Given the effects of hypoxaemia on pulmonary vasoconstriction, cardiorespiratory responses, and DOE, we tested the hypothesis that patients with HFpEF and EIAH (EIAH) would demonstrate higher pulmonary vascular pressures, worse oxygen uptake, and greater DOE compared with patients without EIAH (EIAH).
View Article and Find Full Text PDFJ Public Health (Oxf)
September 2025
Institute of Sociology, University of Neuchâtel, 2000 Neuchâtel, Switzerland.
Background: This article examined to what extent pandemic-related exposures were associated with negative affect up to 2.5 years from the outbreak of the pandemic in Switzerland.
Methods: We drew on longitudinal data from five waves (2018-22) of the Swiss Household Panel, including the pandemic questionnaire collected in May-June 2020 (n = 5657).