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: The social distancing policies adopted during the COVID-19 pandemic forced many individuals to confront their mortality and worry about losing loved ones, making it impossible to say goodbye to them properly. Those not directly experiencing loss were inundated with information about COVID-19-related deaths throughout social media, leading to vicarious grief. This study delved into the long-term effects of direct and vicarious mourning on people's mental health during the COVID-19 pandemic. : A sample of 171 adults (65% female) aged 19-66 years (Mage = 25.8, SD = 8.57) voluntarily participated in an online survey assessing self-reported psychological measures of complicated grief, stress, depression, dispositional neuroticism, trait anxiety, and situational anxiety. : MANOVAs revealed that direct mourning experiences had an extremely severe impact on anxiety, stress, and fear of COVID-19, and a moderate effect on those without personal losses. Indeed, participants reporting high media exposure showed higher scores of depression and stress. : Findings from the current study displayed that during the COVID-19 pandemic, people engaged more in proximal defenses than distal ones, taking health-protective measures, experiencing increased anxiety levels toward virus infection, and feeling distressed. Additionally, vicarious mourning was more strongly associated with depression due to emotional empathy with others.
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http://dx.doi.org/10.3390/jcm13133911 | DOI Listing |
Macromol Biosci
September 2025
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Tandogan, Ankara, Turkey.
The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has highlighted the critical need for safe and effective vaccines. In this study, subunit nanovaccine formulations were developed using the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein encapsulated in polymeric nanoparticles composed of poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-PCL). Two surfactants, poly(vinyl alcohol) (PVA) and sodium cholate (SC), were evaluated during formulation via a modified water-in-oil-in-water (w/o/w) emulsion-solvent evaporation method.
View Article and Find Full Text PDFJAMA
September 2025
Moderna, Inc, Cambridge, Massachusetts.
Clin Transl Sci
September 2025
Food and Drug Administration, Silver Spring, Maryland, USA.
Since the first decentralized clinical trial (DCT) was conducted in 2011, there has been an increased usage of DCT due to its benefits of patient-centricity and generalizability of findings. This trend was further expedited by the global COVID-19 pandemic. We identified 23 case studies across various therapeutic areas and grouped them into different categories according to their purposes-by necessity, for operational benefits, to address unique research questions, to validate innovative digital endpoints, or to validate decentralization as a clinical research platform.
View Article and Find Full Text PDFJAMA
September 2025
Department of Pulmonary and Critical Care Medicine, Xiangtan Central Hospital, Xiangtan, China.
Child Psychiatry Hum Dev
September 2025
School of Psychology, Deakin University, 221 Burwood Highway, Burwood, VIC, 3125, Australia.
The COVID-19 pandemic presented a unique opportunity to investigate the longitudinal associations between parents' pre-pandemic mental health issues and their emotion-related parenting practices during the pandemic, as well as the impact on children's socio-emotional functioning. The present study aimed to: 1) investigate associations between pre-existing parent mental health issues (2019) with children's long-term socio-emotional functioning (2021), via changes in emotion-related parenting practices during the COVID-19 pandemic (2020); and 2) test whether COVID-19 pandemic-related environmental stressors during 2020 and 2021 exacerbated associations between emotion-related parenting practices and children's socio-emotional functioning. Data were drawn from the Child and Parent Emotion Study (CAPES).
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