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Article Abstract
Introduction: [F]FDG PET/CT noninvasively disproves acute kidney allograft rejection (AR) in kidney transplant recipients (KTRs) with suspected AR. However, the correlation of biopsy-based Banff vs. PET/CT-based scores of acute inflammation remains unknown, as does the prognostic performance of [F]FDG PET/CT at one year suspected AR.
Methods: From 2012 to 2019, 114 [F]FDG-PET/CTs were prospectively performed in 105 adult KTRs who underwent transplant biopsies. Ordinal logistic regression assessed the correlation between the extent of histological inflammation and the mean standardized [F]FDG uptake values (mSUV). Functional outcomes of kidney allografts were evaluated at one year post biopsy and correlated to mSUVmean.
Results: A significant correlation between mSUV and acute Banff score was found, with an adjusted of 0.25. The mSUV was significantly different between subgroups of "total i", with 2.30 ± 0.71 in score 3 vs. 1.68 ± 0.24 in score 0. Neither the function nor the survival of the graft at one year was statistically related to mSUV.
Discussion: [F]FDG-PET/CT may help noninvasively assess the severity of kidney allograft inflammation in KTRs with suspected AR, but it does not predict graft outcomes at one year.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235230 | PMC |
| http://dx.doi.org/10.3389/frtra.2023.1236751 | DOI Listing |
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