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Article Abstract
Novel thiazole hybrids were synthesized via thiazolation of 4-phenylthiosemicarbazone (). The anticancer activity against the NCI 60 cancer cell line panel. Methyl 2-(2-((1-(naphthalen-2-yl)ethylidene)hydrazineylidene)-4-oxo-3-phenylthiazolidin-5-ylidene)acetate () showed significant anticancer activity at 10 μM with a mean growth inhibition (GI) of 51.18%. It showed the highest cytotoxic activity against the ovarian cancer OVCAR-4 with an IC of 1.569 ± 0.06 μM. Compound inhibited PI3Kα with IC = 0.225 ± 0.01 μM. Moreover, compound revealed a decrease of Akt and mTOR phosphorylation in OVCAR-4 cells. In addition, antibacterial activity showed that compounds and were the most active against . Compound is a promising molecule that could be a lead candidate for further studies.
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| http://dx.doi.org/10.1080/17568919.2024.2342668 | DOI Listing |
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