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Background: Prediabetes, a high-risk state for developing diabetes, affects more than 1 in 3 adults nationally. However, <5% of people with prediabetes are receiving any treatment for prediabetes. Prior intervention studies for increasing prediabetes treatment uptake have largely focused on individual barriers with few multi-level interventions that address clinician- and system-level barriers.
Objective: To measure the effectiveness of a multi-level intervention on uptake of prediabetes treatment in a primary care clinic.
Design: Pragmatic study of the START (Screen, Test, Act, Refer and Treat) Diabetes Prevention intervention.
Participants: The START Diabetes Prevention intervention was implemented in a suburban primary care clinic outside of Baltimore compared to a control clinic in the same area over a 12-month period.
Intervention: START Diabetes Prevention intervention included a structured workflow, shared decision-making resources and electronic health record clinical decision support tools.
Main Measures: Uptake of prediabetes treatment, defined as Diabetes Prevention Program referral, metformin prescription and/or medical nutrition referral within 30 days of any PCC visit.
Key Results: We demonstrated greater uptake of preventive treatment among patients with prediabetes in the intervention clinic vs. control clinic receiving usual care (11.6% vs. 6.7%, p<0.001). More patients in the intervention vs. control clinic reported their PCC discussed prediabetes with them (60% vs. 48%, p=0.002) and more felt overall that they understood what their doctor was telling them about prediabetes and that their opinion was valued. The START Diabetes Prevention Strategy had greater acceptability and usefulness to PCCs at the study end compared to baseline.
Conclusions: A low-touch multi-level intervention is effective in increasing prediabetes treatment uptake. The intervention was also acceptable and feasible for clinicians, and enhanced patient understanding and discussions of prediabetes with their clinicians.
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http://dx.doi.org/10.1101/2024.06.10.24308653 | DOI Listing |
BMJ
September 2025
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Objective: To determine the effect of a prepregnancy lifestyle intervention on glucose tolerance in people at higher risk of gestational diabetes mellitus.
Design: Single centre randomised controlled trial (BEFORE THE BEGINNING).
Setting: University hospital in Trondheim, Norway.
Cureus
August 2025
Obstetrics and Gynecology, Yokohama Rosai Hospital, Yokohama, JPN.
Introduction Pelvic organ prolapse (POP) affects up to 30% of women during their lifetime and significantly impairs quality of life. In Japan, laparoscopic sacrocolpopexy was covered by national insurance starting in 2014 and has become an established treatment option. Objective This study evaluates the long-term outcomes of POP surgery, including recurrence and complications, seven years after the introduction of sacrocolpopexy at our institution.
View Article and Find Full Text PDFArch Esp Urol
August 2025
Urology Department, Hospital and University Complex of Albacete, 02006 Albacete, Spain.
Background: Delayed graft function is a common situation that leads to increased long-term rates of graft rejection and loss. It is seen increasingly more often, as the use of kidneys from donors after controlled cardiac death has become more widespread. This study aimed to identify factors contributing to its onset and determine how these factors may influence graft survival.
View Article and Find Full Text PDFAm J Prev Med
September 2025
Arnold School of Public Health, University of South Carolina.
Introduction: Summer day camps (SDC) can mitigate summer weight gain by providing a structured daily environment that promotes healthy behaviors, but SDCs are often cost prohibitive to families with low-income. This study evaluated the cost effectiveness of providing free SDC to disadvantaged children to prevent summer weight gain.
Methods: 422 children from a low-income school district in South Carolina were recruited and randomly assigned to receive 8-10 weeks of free SDC or to experience summer as usual in 2021-2023.
PLoS One
September 2025
Chilean Invasive Mycosis Network, Santiago, Chile.
Background: Invasive mold diseases (IMDs) are a severe complication of immunocompromised subjects and an emerging problem among severely ill, apparently immunocompetent patients. The aim of this study was to describe the epidemiological and clinical features of IMDs in Chile.
Methods: Prospective study of IMD cases in children and adults from 11 reference hospitals in Chile from May 2019 to May 2021.