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Purpose: To acquire accurate volumetric multi-channel maps in under 14 s whole-brain or 23 heartbeats whole-heart for parallel transmit (pTx) applications at 7 T.
Theory And Methods: We evaluate the combination of three recently proposed techniques. The acquisition of multi-channel transmit array maps is accelerated using transmit low rank (TxLR) with absolute mapping (Sandwich) acquired in a time-interleaved acquisition of modes (B1TIAMO) fashion. Simulations using synthetic body images derived from Sim4Life were used to test the achievable acceleration for small scan matrices of 24 × 24. Next, we evaluated the method by retrospectively undersampling a fully sampled library of nine subjects in the brain. Finally, Cartesian undersampled phantom and in vivo images were acquired in both the brain of three subjects (8Tx/32 receive [Rx]) and the heart of another three subjects (8Tx/8Rx) at 7 T.
Results: Simulation and in vivo results show that volumetric multi-channel maps can be acquired using acceleration factors of 4 in the body, reducing the acquisition time to within 23 heartbeats, which was previously not possible. In silico heart simulations demonstrated a RMS error to the fully sampled native resolution ground truth of 4.2° when combined in first-order circularly polarized mode (mean flip angle 66°) at an acceleration factor of 4. The 14 s 3D maps acquired in the brain have a RMS error of 1.9° to the fully sampled (mean flip angle 86°).
Conclusion: The proposed method is demonstrated as a fast pTx calibration technique in the brain and a promising method for pTx calibration in the body.
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http://dx.doi.org/10.1002/mrm.30201 | DOI Listing |
Ther Innov Regul Sci
September 2025
Fiocruz Brasilia, ColLaboratory of Science, Technology, Innovation and Society (CTIS), Brasilia, DF, Brazil.
Purpose: To identify and review scientific evidence from experimental studies utilizing unmanned aerial vehicles (UAVs) to transport samples for the diagnosis of COVID-19 and tuberculosis (TB). This exploratory study aims to support the future development of UAVs for transporting biological samples within the Brazilian Unified Health System (SUS).
Methods: This scoping review defined its eligibility criteria using the PECO acronym, focusing on: Population: biological samples for diagnosing COVID-19 or TB; Exposure: UAV transportation; Comparator: land transportation; Outcomes: Cost, effectiveness, methods for sample preservation, flight parameters (time, altitude, speed, distance), and quality of transported samples.
J Affect Disord
September 2025
Department of Clinical Psychology and Psychotherapy for Children and Adolescents, Friedrich-Alexander-Universität Erlangen, Nürnberg, Germany; German Center for Mental Health (DZPG), Tübingen, Germany.
Numerous clinical and epidemiological studies have demonstrated altered immune activity in adult depression patients, yet comparable data in youth are scarce. This study investigated the relationship between depression severity and peripheral immune measures in a clinical sample of children and adolescents. We analyzed 1198 blood samples from 819 patients (age range: 8-18 years) diagnosed with mild, moderate, or severe depression disorder using ICD-10 criteria.
View Article and Find Full Text PDFMol Pharmacol
August 2025
Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland. Electronic address:
Although multiparameter cellular morphological profiling methods and three-dimensional (3D) biological model systems can potentially provide complex insights for pharmaceutical discovery campaigns, there have been relatively few reports combining these experimental approaches. In this study, we used the U87 glioblastoma cell line grown in a 3D spheroid format to validate a multiparameter cellular morphological profiling screening method. The steps of this approach include 3D spheroid treatment, cell staining, fully automated digital image acquisition, image segmentation, numerical feature extraction, and multiple machine learning approaches for cellular profiling.
View Article and Find Full Text PDFEpilepsia
September 2025
Department of Pharmacology and Therapeutics, University of Liverpool, UK.
Objective: A key diagnostic challenge at "first seizure" clinic appointments is determining whether the reported event was epileptic. Witness accounts are often critical, yet such appointments typically occur weeks after the event. Guidelines recommend review within 2 weeks.
View Article and Find Full Text PDFMult Scler Relat Disord
September 2025
Center for Neuropsychology and Neuroscience Research, Kessler Foundation, West Orange, NJ, USA; Department of Physical Medicine and Rehabilitation, Rutgers NJ Medical School, Newark, NJ, USA. Electronic address:
Background: Safety, adherence, and compliance have been poorly-characterized in randomized controlled trials (RCTs) of exercise training within multiple sclerosis (MS) research. The MoXFo initiative recently proposed standard criteria for defining exercise safety, adherence, and compliance, yet these criteria have infrequently been applied within an exercise training RCT involving people with MS.
Objective: This study applied published criteria for characterizing safety, adherence, and compliance within a RCT that compared 12-weeks of supervised treadmill walking exercise (TMWX) training (intervention condition) with 12-weeks of stretching-and-toning (active control condition) among fully-ambulatory persons with MS who demonstrated slowed cognitive processing speed (CPS).