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Step-up variations are frequently used in sports performance to develop coordinated and powerful movements that transfer to running. This study aimed to quantify the kinetic characteristics of the first foot contact of four different step-up variations. Ten professional rugby league players participated in this study and performed the Barbell One Box Step-Up with Catch (BB1), Barbell Two Box Step-Up (BB2), Vest Two Box Run (VEST) and Step-Up Jump (JUMP) as part of routine in-season strength training sessions during one season. Peak force, total impulse and maximal rate of force development (RFD) were measured from first foot contact on the step-up box. Significantly greater peak force and RFD were observed in JUMP than any other variation (standardized mean difference; SMD: 3.9-5.5; p < 0.001). Total impulse was equal between JUMP and BB1, and significantly greater in JUMP than BB2 and VEST (SMD: 1.3-2.3; p < 0.001), and in BB1 than BB2 and VEST (SMD: 1.8-2.8; p < 0.001). Significantly larger peak force and RFD were observed in BB2 and VEST than BB1 (SMD: 0.6-0.7) and in total impulse in BB2 than VEST (SMD: 1.6) (p < 0.05). The results of this study highlight that step-up exercise variations maximize different kinetic characteristics, which may transfer differently to athlete running performance.
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http://dx.doi.org/10.1002/ejsc.12150 | DOI Listing |
Sci Rep
January 2025
Power Electronics Research Laboratory (PERL), Faculty of Electrical Engineering, Sahand University of Technology, Tabriz, Iran.
This research paper presents a high-gain DC-DC converter with ultra-step-up voltage gain capability. The proposed converter is synthesized from a two-phase interleaved boost converter (IBC), and its voltage gain is doubled by adopting a voltage lift capacitor. To enhance its voltage gain capability, a floating capacitor-based gain extension cell is adopted subsequently.
View Article and Find Full Text PDFClin Pharmacokinet
January 2025
Clinical Pharmacology and Quantitative Science, Genmab, Plainsboro, NJ, USA.
Background And Objectives: Epcoritamab is a CD3xCD20 bispecific antibody approved for the treatment of adults with different types of relapsed or refractory (R/R) B cell non-Hodgkin lymphoma (B-NHL) after ≥ 2 lines of systemic therapy. Here we report the first results from a population pharmacokinetic model-based analysis using data from 2 phase 1/2 clinical trials (EPCORE NHL-1, NCT03625037 and EPCORE NHL-3, NCT04542824) evaluating epcoritamab in patients with R/R B-NHL.
Methods: Plasma concentration-time data included 6819 quantifiable pharmacokinetic samples from 327 patients with R/R B-NHL.
Health Serv Insights
December 2024
Centre for Care Research, Department of Health Sciences in Gjøvik, Norwegian University of Science and Technology (NTNU), Gjøvik, Norway.
Background: Norwegian Municipal Inpatient Acute Care (MIPAC) services were established as part of the 2012 Coordination Reform. The intention was to prevent unnecessary hospital admissions by redirecting and maintaining less urgent patients at the primary care level, which provides inpatient acute healthcare services closer to patients' home. However, the role MIPAC plays in the patient trajectory and how trajectories vary across different units and settings is less clear.
View Article and Find Full Text PDFAbdom Radiol (NY)
March 2025
Department of Surgical Gastroenterolgy, All India Institute of Medical Sciences, Bhubaneswar, 751019, India.
Curr Med Res Opin
October 2024
Mount Sinai School of Medicine, New York, NY, USA.