Immunotherapy in locally advanced cervical cancer: Integrating KEYNOTE-A18 into management strategies.

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Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Published: June 2024


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Article Abstract

In locally advanced cervical cancer (LACC), the benefit of PD-1 blockade was unknown. In KEYNOTE-A18, Lorusso et al. compared the efficacy and safety of adding pembrolizumab to chemoradiation in LACC and demonstrated favorable outcomes. Given multiple approved indications of pembrolizumab in cervical cancer, strategies for optimal integration into management will be needed to maximize overall survival.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004455PMC
http://dx.doi.org/10.1016/j.medj.2024.05.001DOI Listing

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