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The performance of high-speed intensity modulation direct detection (IM-DD) transmissions is severely degraded due to the occurrence of multipath interference (MPI), especially when a higher-order modulation format is utilized. Here, we propose and demonstrate, for the first time to the best of our knowledge, that a Nyquist subcarrier modulation (Nyquist-SCM) format inherently exhibits resistance to the MPI. We experimentally evaluate the MPI tolerance by transmitting 56 Gbit/s PAM-4 signals and Nyquist-SCM 16QAM signals over the 2 km standard single-mode fiber (SSMF) when the C-band semiconductor laser with a linewidth of 1.7 MHz is utilized. In comparison with the PAM-4 format, the Nyquist-SCM 16QAM format can lead to an enhanced MPI tolerance of 4 dB at the KP4-FEC threshold of BER = 2 × 10. In addition, even with the help of MPI mitigation for the PAM-4 signals based on two newly reported methods, the utilization of Nyquist-SCM 16QAM signal can still guarantee an improved MPI tolerance of 1 dB.
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http://dx.doi.org/10.1364/OL.528103 | DOI Listing |
Pest Manag Sci
July 2025
College of Artificial Intelligence, Shenyang Normal University, Shenyang, China.
Background: Quantifying tolerances or legal maximum residue limits (MRLs) of pesticide in/on food commodities is of significance to enforce the surveillance of food safety/quality and good agricultural practices (GAP). Current in silico models mostly focus on estimating field residue levels, for example via in situ or field maximum residue levels (in situ MRLs), retention time and dissipation half-life. In silico modelling of residue tolerances involves more complicated processes (e.
View Article and Find Full Text PDFMultipath interference (MPI) poses a significant challenge for 4-level pulse amplitude modulation (PAM4) signals in short-reach intensity modulation and direct detection (IM/DD) interconnect systems. MPI, arising from signal reflections due to the multiple fiber connectors, introduces irregular intensity fluctuations across PAM4 levels, severely degrading the system performance. This work proposes an MPI noise mitigation scheme, instantaneous mean intensity addressing (IMIA), which suppresses the MPI noise by utilizing an instantaneous mean intensity table and an MPI noise table for real-time noise extraction and removal.
View Article and Find Full Text PDFNeurodegenerative diseases, such as amyotrophic lateral sclerosis, are often associated with mutations in stress granule proteins. Aberrant stress granule condensate formation is associated with disease, making it a potential target for pharmacological intervention. Here, we identified lipoamide, a small molecule that specifically prevents cytoplasmic condensation of stress granule proteins.
View Article and Find Full Text PDFAME Case Rep
January 2025
Clinical Research and Practice Department, El.En. Group, Florence, Italy.
Background: As a prevalent condition of the pilosebaceous unit, acne vulgaris affects approximately 85% of people between the ages of 12 and 25 years. Among the patients, 47% report having acne scars. Considering the characteristics of the dye laser, we believe that this device can be a feasible solution for treating these facial skin imperfections.
View Article and Find Full Text PDFJ Nucl Med
April 2025
Research and Development Centre, Synektik SA, Warsaw, Poland.
A first-in-human phase I clinical study aimed to assess the safety profile, radiation dosimetry, and biodistribution of a potential cardiac PET myocardial perfusion imaging tracer, [F]SYN2 (F-labeled acridine derivative), in healthy subjects. [F]SYN2 intravenous administration with PET imaging was performed on healthy volunteers, and sequential whole-body imaging was performed over 4 h. Blood and urine samples were collected for up to 240 min.
View Article and Find Full Text PDF