98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11263520 | PMC |
http://dx.doi.org/10.1007/s40120-024-00638-1 | DOI Listing |
Mol Divers
September 2025
Information Technology and Computing Applications, Vignan's Foundation for Science, Technology and Research (Deemed to be University), Guntur, India.
J Agric Food Chem
September 2025
School of Chemical Engineering and Technology, Zhengzhou University, Zhengzhou 450001, China.
d-Amino acid oxidase from (DAAO) is valuable for pharmaceutical and chemical synthesis due to its high enantioselectivity, but its poor thermostability limits extensive application. This study proposed a synergistic strategy of "sequence consensus design coupled with structure modification" to enhance DAAO thermostability. Through homologous sequence analysis and greedy algorithm-based optimization, a triple mutant M3 (S18T/V7I/Y132F) was obtained, showing a 3.
View Article and Find Full Text PDFJTCVS Open
August 2025
Division of Cardiovascular Surgery, Children's National Heart Institute, Children's National Hospital, Washington, DC.
Objectives: We sought to review the outcomes of patients with Ebstein anomaly (EA) after the Fontan operation.
Methods: Patients with EA were identified from a large binational registry about the Fontan operation. Data were collected from hospital records, registry data, and clinical correspondence.
IEEE J Biomed Health Inform
September 2025
Drug-target interaction (DTI) identification is of great significance in drug development in various areas, such as drug repositioning and potential drug side effects. Although a great variety of computational methods have been proposed for DTI prediction, it is still a challenge in the face of sparsely correlated drugs or targets. To address the impact of data sparsity on the model, we propose a multi-view neighborhood-enhanced graph contrastive learning approach (MneGCL), which is based on graph clustering according to the adjacency relationship in various similarity networks between drugs or targets, to fully exploit the information of drugs and targets with few corrections.
View Article and Find Full Text PDFJ Comput Soc Sci
September 2025
Chair of Research Methods in Developmental and Educational Sciences, Institute of Education, University of Zurich, Zurich, Switzerland.
School curricula guide the daily learning activities of millions of students. They embody the understanding of the education experts who designed them of how to organize the knowledge that students should acquire in a way that is optimal for learning. This can be viewed as a learning 'theory' which is, nevertheless, rarely put to the test.
View Article and Find Full Text PDF