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Metaplastic thymoma is a rare biphasic thymic tumor with indolent behavior and recurrent gene rearrangement. Although the diagnosis of this tumor is usually straightforward based on hematoxylin and eosin (H&E) findings alone, cases with scant spindle-cell ("pseudosarcomatous stroma") components can be easily confused with more commonly occurring type A thymoma. We present a case of metaplastic thymoma with a sparse stroma-like spindle-cell component, discussing its histological and immunohistochemical hints and drawing attention to the visual similarity to type A thymoma. This is also the first published case of metaplastic thymoma with associated psoriasis.
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http://dx.doi.org/10.7759/cureus.60136 | DOI Listing |
Indian J Pathol Microbiol
August 2025
Department of Histopathology, Lilavati Hospital and Research Centre, Mumbai, Maharashtra, India.
Though thymomas are the commonest neoplasms of the anterior mediastinum, metaplastic thymoma is an extremely rare subtype, with only a few reported cases. It was included in the 2004 WHO classification of thymic epithelial tumors and exhibits a biphasic morphology distinct from the conventional thymomas. It has a benign clinical course with extremely rare cases showing recurrence and malignant transformation.
View Article and Find Full Text PDFJ Thorac Imaging
August 2025
Department of Radiology; †Division of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine.
Acta Oncol
January 2025
Department of Oncology, Copenhagen University Hospital, Copenhagen, Denmark.
Background And Purpose: We report the incidence, characteristics, and comorbidities of the complete unselected Danish cohort of patients with thymic epitheliums (TETs), which may serve as evidence for guiding treatment, surveillance, and counselling of TET patients.
Patients And Methods: All patients diagnosed with TETs from January 1st, 2015, to December 31st, 2020, were identified using the Danish Pathology Data Registry. Data on patient characteristics, comorbidities, and tumor histology were collected from electronic medical records available for all patients.
Virchows Arch
September 2024
Institute of Pathology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany.
AME Case Rep
May 2024
Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin, China.