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Focusing light down to subwavelength scales to enhance the light-matter interaction has been highly sought after, which has promoted significant researches and applications in nanophotonics. Plasmonic nanoantennae are a significant tool to achieve this goal since they can confine light into ultra-small volumes far below the diffraction limit. However, metallic materials have the property of central symmetry, resulting in weak second-order nonlinear effects. Here, we design plasmonic bowtie nanoantennae on thin-film lithium niobate (TFLN) for deep-subwavelength light confinement to boost the second-harmonic generation (SHG) in TFLN via the plasmonic hotspot enhancement. The SHG enhancement factor of about 20 times as compared to unpatterned TFLN is achieved in the experiment when resonantly excited by femtosecond laser. This work proposes a route for subwavelength nonlinear optics on the TFLN platform.
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http://dx.doi.org/10.1364/OE.520773 | DOI Listing |
ACS Appl Mater Interfaces
September 2025
College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, P. R. China.
Exhaled breath analysis offers noninvasive, early lung cancer detection via volatile organic compound (VOC) biomarkers, surpassing blood-based methods. Surface-enhanced Raman spectroscopy (SERS) is ideal for this purpose, combining molecular fingerprint specificity with single-molecule sensitivity. However, conventional SERS substrates face a fundamental limitation: while porous materials such as metal-organic frameworks effectively adsorb VOCs through their subnanometer pores (0.
View Article and Find Full Text PDFFood Chem
August 2025
College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, PR China. Electronic address:
Tetrodotoxin (TTX) is a potent neurotoxic marine biotoxin that poses severe health risks. To address this challenge, a dual-mode detection strategy was developed based on TTX-induced conformational changes in hairpin probes (HP), regulation of Au NPs aggregation to modulate localized surface plasmon resonance, and hotspot formation for colorimetric and surface-enhanced Raman spectroscopy (SERS) signal detection. This method demonstrates higher specificity than ion-induced aggregation.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
August 2025
European Laboratory for non-linear spectroscopy (LENS), Via Nello Carrara 1, Sesto Fiorentino, (FI) 50019, Italy; National Institute of Optics (INO), National Research Council, Via Nello Carrara 1, Sesto Fiorentino, (FI) 50019, Italy.
Multifunctional magneto-plasmonic nanoparticles (MP-NPs) are attracting increasing interest for biomedical applications due to their dual magnetic and optical properties. However, existing synthesis protocols for MP-NPs could be limited by harsh conditions or lengthy, complex procedures. These limitations can hinder the development of nanosystems that work effectively in biological dispersion.
View Article and Find Full Text PDFAnal Bioanal Chem
August 2025
Nick Holonyak Jr. Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
The unique optical interaction of species such as nanomaterials, proteins, viruses, antibodies, microRNA, and exosomes with the one-dimensional grating-based photonic crystals (PCs) has been leveraged in their detection using photonic crystal absorption microscopy (PRAM). While the principle and fundamental mechanism of such interfacial interactions are well delineated using wavelength and intensity modulations associated with the guided-mode resonance (GMR) of the PC, the effect of nano-assemblies in place of nanoparticles (NPs) has not been reported previously. In this work, the fundamental limitations observed with pristine NPs are overcome through the use of tunable AuNP assemblies synthesized via adiabatic cooling technology, where tunable nano-assemblies are obtained by subjecting the respective NPs to - 196 °C.
View Article and Find Full Text PDFACS Appl Bio Mater
August 2025
Department of Chemistry and Biochemistry, Jackson State University, Jackson, Mississippi 39217, United States.
Antibiotic-resistant superbugs are a global threat that are predicted to become the leading cause of death worldwide. To effectively combat superbugs, accurate prediction of antibiotic susceptibility is crucial, which takes more than 24 h in clinics now. Herein, we report doxycycline (DX) antibiotic-decorated silver nanoparticle (AgNP)-based plasmonic metal-enhanced fluorescence (PMEF) nanoplatforms for accurate, rapid, and sensitive prediction of antibiotic susceptibility against different superbugs.
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