Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161895 | PMC |
| http://dx.doi.org/10.1093/ofid/ofae291 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Co-infection with two α-synuclein strains reveals novel synergistic interactions.
bioRxiv
August 2025
Department of Microbiology, Immunology, & Pathology and Prion Research Center, Colorado State University, Fort Collins, CO, USA.
In synucleinopathies, the protein α-synuclein misfolds into Lewy bodies (LBs) in patients with Lewy body disease (LBD) or into glial cytoplasmic inclusions (GCIs) in patients with multiple system atrophy (MSA). The ability of a single misfolded protein to cause disparate diseases is explained by the prion strain hypothesis, which argues that protein conformation is a major determinant of disease. While structural, biochemical, and biological studies show that LBD and MSA patient samples contain distinct α-synuclein strains, we recently reported the unexpected finding of a novel α-synuclein strain in a Parkinson's disease with dementia patient sample containing GCI-like co-pathology along with widespread LB pathology.
View Article and Find Full Text PDFUrban streams as hotspots of carbon dioxide and methane diffusive emissions compared to small ponds.
Water Res
August 2025
Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China. Electronic address:
Streams and ponds significantly contribute to the global freshwater carbon gases budget. To understand the role of urbanization in affecting aquatic carbon emissions, here we examined the carbon dioxide (CO) and methane (CH) concentrations and diffusive emissions from streams and small ponds across three headwater catchments with varied urbanization intensities in the upper Yangtze River. We found that riverine partial pressure of CO (pCO) and dissolved CH concentration (dCH) increased, while pond pCO and dCH decreased as urban land proportion of catchments increased from 1.
View Article and Find Full Text PDFEndocytosis is essential for cysteine-deprivation-induced ferroptosis.
Mol Cell
September 2025
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:
Ferroptosis is a form of cell death caused by iron-dependent phospholipid peroxidation and subsequent membrane rupture. Autophagic degradation of the iron-storage protein ferritin promotes ferroptosis by increasing cytosolic bioactive iron, presumably explaining how lysosomal inhibitors suppress ferroptosis. Surprisingly, we found that lysosomal inhibitors suppress cysteine-deprivation-induced (CDI) ferroptosis, even in autophagy-defective cells, and subsequently discovered that clathrin-mediated endocytosis (CME) of transferrin is essential for CDI ferroptosis.
View Article and Find Full Text PDFPROTAC Enabling Formulation : Implications of the Polymeric Carrier Eudragit E PO.
Mol Pharm
August 2025
Institute of Pharmacy, Faculty I of Natural Sciences, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Strasse 3, Halle (Saale) 06120, Germany.
Proteolysis targeting chimeras (PROTACs) are heterobifunctional degraders with a unique mode of action that permits access to "undruggable" targets. These molecules pose challenges in terms of solubility and bioavailability due to their physicochemical properties. So far, very little information is available on the potential of enabling formulations of PROTACs in pharmacokinetic studies.
View Article and Find Full Text PDFAbsence of Syndactyly Associated With the Common Apert FGFR2 S252W Mutation: A Clinical Report and Likely Molecular Explanation.
Am J Med Genet A
August 2025
Clinical Genetics, North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Apert syndrome is a recognizable craniofacial condition characterized by craniosynostosis, hypertelorism, exorbitism, midface hypoplasia, and complex symmetrical bony and cutaneous 'mitten' syndactyly of all four limbs. Around 98% of affected patients have one of two heterozygous missense variants in the FGFR2 gene, encoding either p.(Ser252Trp) (S252W) or p.
View Article and Find Full Text PDF