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Since January 2024, Italy experiences a pertussis outbreak, primarily affecting neonates and unvaccinated infants at high risk of severe complications and mortality; 11 major paediatric centres noted 108 hospitalisations and three deaths by 10 May. The outbreak reflects increased circulation of and non-adherence to immunisation recommendations during pregnancy. Public health interventions, including maternal immunisation, vaccination of infants as early as possible and post-exposure prophylaxis, are critical for reducing the burden of pertussis and preventing further mortality.
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http://dx.doi.org/10.2807/1560-7917.ES.2024.29.23.2400301 | DOI Listing |
BMC Public Health
September 2025
Research Institute for Sustainable Development (IRD) EMR 271, University of Bordeaux, National Institute for Health and Medical Research (INSERM), UMR 1219, Bordeaux Population Health Research Centre, Bordeaux, France.
Background: Malaria remains a major health challenge in sub-Saharan Africa, especially for children under five. The World Health Organization (WHO) recommends perennial malaria chemoprevention (PMC) to children in areas of medium to high perennial transmission. In Togo, since 2022, a pilot project has leveraged the Expanded Program on Immunization (EPI) to deliver PMC to children under two years; however, the extent to which PMC achieves its desired outcome may depend on EPI performance.
View Article and Find Full Text PDFInfect Drug Resist
August 2025
Department of Child Health Care, Children's Hospital, Zhejiang University School of Medicine, National Children's Regional Medical Center, National Children's Regional Medical Center, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, People's Republic of China.
Background: Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis, posing a significant health threat to children. Despite vaccination efforts, a resurgence of pertussis has been observed globally, especially during and after the COVID-19 pandemic. This study aims to investigate the epidemiological trends and characteristics of pertussis among pediatric patients during and after the COVID-19 pandemic in East China.
View Article and Find Full Text PDFIJID Reg
September 2025
Department of Infectious Diseases, Okayama University Hospital, Okayama, Japan.
Pertussis, a highly contagious respiratory infection caused by , has demonstrated a global resurgence in the post-COVID-19 era, with the emergence of macrolide-resistant strains. In Japan, the routine immunization schedule for pertussis remains limited compared with international standards, leaving young populations under-immunized and at elevated risk of infection. Despite international recommendations for booster vaccinations during adolescence, Japan currently provides only a four-dose primary series during infancy, without subsequent boosters.
View Article and Find Full Text PDFRespirology
August 2025
First Department of Internal Medicine, Division of Respiratory Medicine, Infectious Disease and Allergology, Kansai Medical University, Osaka, Japan.
Since public health measures against COVID-19 were relaxed, widespread outbreaks of respiratory infections such as influenza and respiratory syncytial virus (RSV), as well as infectious diseases transmitted by droplets and droplet nuclei, have been reported around the world. While there is evidence of antiviral drug efficacy against non-severe influenza, the emergence of two genetic mutations (I223V or S247N) that reduce susceptibility to neuraminidase inhibitors has been confirmed. Influenza vaccines are less effective in older people than in younger people; so high-dose influenza vaccines are recommended.
View Article and Find Full Text PDFEuro Surveill
August 2025
Meyer Children's Hospital, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Florence, Italy.
BACKGROUNDPertussis is a highly contagious respiratory infection caused by . Vaccination against pertussis is included in the Italian vaccination programme with three doses administered at 3, 5 and 11 months, booster doses at 6 and 12-18 years, and every 10 years. Vaccination coverage in Tuscany is high among infants (97.
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