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Stimuli-responsive polymeric micelles have emerged as a revolutionary approach for enhancing the in vivo stability, biocompatibility, and targeted delivery of functional nanoparticles (FNPs) in biomedicine. This article comprehensively reviews the preparation methods of these polymer micelles, detailing the innovative strategies employed to introduce stimulus responsiveness and surface modifications essential for precise targeting. We delve into the breakthroughs in utilizing these micelles to selectively deliver various FNPs including magnetic nanoparticles, upconversion nanoparticles, gold nanoparticles, and quantum dots, highlighting their transformative impact in the biomedical realm. Concluding, we present an insight into the current research landscape, addressing the challenges at hand, and envisioning the future trajectory in this burgeoning domain. Join us as we navigate the exciting confluence of polymer science and nanotechnology in reshaping biomedical solutions.
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http://dx.doi.org/10.1016/j.cis.2024.103206 | DOI Listing |
RSC Adv
September 2025
School of Pharmaceutical Sciences, Nanjing Tech University Nanjing 211816 China
Diabetic wounds present persistent challenges due to impaired healing, recurrent infection, oxidative stress, and dysregulated glucose metabolism. Bioinspired polymeric microneedle (MN) patches have emerged as multifunctional platforms capable of penetrating the stratum corneum to deliver therapeutics directly into the dermis, enabling glucose regulation, antimicrobial action, reactive oxygen species (ROS) modulation, and proangiogenic stimulation. Recent experimental evidence has demonstrated that the integration of glucose oxidase-loaded porous metal-organic frameworks, photothermal nanomaterials, and antioxidant hydrogels within dissolvable MNs achieves synergistic bactericidal effects, accelerates collagen deposition, and enhances neovascularization in diabetic wound models.
View Article and Find Full Text PDFACS Appl Bio Mater
September 2025
Department of Chemistry, Indian Institute of Technology Patna, Patna, Bihta, Bihar 801106, India.
Development of suitable carbohydrate-decorated, biocompatible, and stimuli-responsive fluorescent microgels that can selectively bind and detect proteins (such as lectins) is an important research topic. Herein, we report the development of mannose-decorated, dual-stimuli (temperature and pH)-responsive fluorescent poly(aminoamide) microgels, which can selectively bind to and thereby detect the presence of concanavalin A (Con A). The resultant stimuli-responsive microgels have a lower critical solution temperature (VPTT) of 37.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
Department of Bioengineering, Yildiz Technical University, Istanbul, 34722, Turkey.
Conductive nanocomposite hydrogels (CNHs) represent a promising tool in neural tissue engineering, offering tailored electroactive microenvironments to address the complex challenges of neural repair. This systematic scoping review, conducted in accordance with PRISMA-ScR guidelines, synthesizes recent advancements in CNH design, functionality, and therapeutic efficacy for central and peripheral nervous system (CNS and PNS) applications. The analysis of 125 studies reveals a growing emphasis on multifunctional materials, with carbon-based nanomaterials (CNTs, graphene derivatives; 36.
View Article and Find Full Text PDFRSC Adv
September 2025
Chemistry Department, Faculty of Science, Cairo University Cairo Egypt
The field of biomaterials has evolved rapidly with the introduction of time as a transformative factor, giving rise to four-dimensional (4D) materials that can dynamically change their structure or function in response to external stimuli. This review presents a comprehensive comparison between traditional three-dimensional (3D) and emerging 4D biomaterials, highlighting the key distinctions in design, adaptability, and functionality. We explore the development of smart biomaterials at the core of 4D systems, including stimuli-responsive polymers, shape-memory materials, and programmable hydrogels.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Division Macromolecular Chemistry, Leibniz Institute of Polymer Research Dresden, Hohe Strasse 6, Dresden, 01069, Germany.
Stimuli-responsive (multiphase) coacervates deserve significant attention as cell-like entities that can adapt to their environment and undergo morphological reconfiguration. In this study, a tandem-triggered transition system is presented that enables the transformation of single-phase coacervates into multiphase structures through the sequential application of two external stimuli: pH and salt concentration. A polyanion containing acid-labile amide bond is incorporated into the membrane-less coacervates.
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