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Introduction: Although behavioural interventions have been found to help control type 2 diabetes (T2D), it is important to understand how the delivery context can influence implementation and outcomes. The NHS committed to testing a low-calorie diet (LCD) programme designed to support people living with excess weight and T2D to lose weight and improve diabetes outcomes. Understanding what influenced implementation during the programme pilot is important in optimising rollout. This study explored the transferability of the NHS LCD Programme prior to wider adoption.
Methods: Twenty-five interviews were undertaken with stakeholders involved in implementing the LCD programme in pilot sites (health service leads, referring health professionals and programme deliverers). Interviews with programme participants (people living with T2D) were undertaken within a larger programme of work, exploring what worked, for whom and why, which is reported separately. The conceptual Population-Intervention-Environment-Transfer Model of Transferability (PIET-T) guided study design and data collection. Constructs of the model were also used as a deductive coding frame during data analysis. Key themes were identified which informed recommendations to optimise programme transfer.
Results: Population: Referral strategies in some areas lacked consideration of population characteristics. Many believed that offering a choice of delivery model would promote acceptability and accessibility of the eligible population.
Intervention: Overall, stakeholders had confidence in the LCD programme due to the robust evidence base along with anecdotal evidence, but some felt the complex referral process hindered engagement from GP practices.
Environment: Stakeholders described barriers to accessing the programme, including language and learning difficulties. Transferability: Multidisciplinary working and effective communication supported successful implementation.
Conclusion: Referral strategies to reach underrepresented groups should be considered during programme transfer, along with timely data from service providers on access and programme benefits. A choice of delivery models may optimise uptake. Knowledge sharing between sites on good working practices is encouraged, including increasing engagement with key stakeholders.
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http://dx.doi.org/10.1111/dme.15354 | DOI Listing |
FASEB J
August 2025
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Refined control of intrinsic and extrinsic signals is critical for specific neuronal differentiation. Here, we differentiated human induced pluripotent stem cells (hiPSCs) from three different healthy donors into neural stem cells (NSCs) and floor plate progenitors (FPPs; progenitors of dopaminergic neurons) and further performed intracellular and extracellular vesicles' (EVs) miRNA profiling. While NSC and FPP cells differed significantly in levels of only 8 intracellular miRNAs, their differences were more evident in the EV miRNAs with 27 differentially expressed miRNAs.
View Article and Find Full Text PDFMaterials (Basel)
August 2025
School of Biomedical Engineering, Korea University, Seoul 02841, Republic of Korea.
This study aimed to develop dental resin composites containing ZnO/SiO ceramic particles as an antimicrobial filler for producing provisional dental restorations using the lithography-based liquid crystal display (LCD) 3D printing technique. Three types of dental resin-ceramic composites with different filler contents (0 wt%, 5 wt%, and 10 wt%) were prepared to offer high antimicrobial efficacy. Printing parameters, particularly off-time, were optimized for each composition to achieve high-quality prints.
View Article and Find Full Text PDFNutrition
July 2025
Laboratory of Health Science, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Minas Gerais, Montes Claros, Brazil.
Objectives: To investigate the associations and changes of adherence to a low-carbohydrate diet (LCD) on binge eating and food craving among Brazilian university students over a 3-mo period.
Methods: A two-wave evaluation study analyzing secondary data from a previously conducted cross-sectional study. The study was conducted remotely via online surveys targeting university students in southeastern Brazil.
J Funct Biomater
July 2025
Advanced Dental Device Development Institute (A3DI), Kyungpook National University, Daegu 41940, Republic of Korea.
The dimensional accuracy of the intaglio surface of complete dentures fabricated using liquid crystal display (LCD) three-dimensional (3D) printing might be influenced by the build angle and post-processing storage conditions. This study evaluated the effect of build angle and natural light exposure duration on the intaglio surface trueness of maxillary complete denture bases. Standardized denture base designs (2 mm uniform thickness) were fabricated using an LCD 3D printer (Lilivis Print; Huvitz, Seoul, Republic of Korea) at build angles of 0°, 45°, and 90° ( = 7 per group).
View Article and Find Full Text PDFBiol Trace Elem Res
August 2025
Animal Science and Technology College, Henan University of Science and Technology, Luoyang, 471003, China.
In this study, 360 healthy juvenile largemouth bass, averaging body weights of 11.26 ± 0.49 g, were randomly assigned to four experimental groups.
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