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Objective: Vitamin B17 tablets are sold (online) as an alternative cancer therapy medication. Its use however is not benign, given that it is metabolised into hydrogen cyanide. We aimed to measure the number of calls received by the New South Wales Poisons Information Centre (NSW PIC) regarding Amygdalin exposures.
Methods: A retrospective review of all amygdalin/cyanogenic glycoside product ingestion exposure calls to NSW PIC between 2015 and 2022.
Results: There were 120 unique exposure calls. Eighty-two (68%) were regarding minor exposures, with the remaining 38 (32%) of calls involving patients who had either a signifcant history or symptoms to prompt referral to hospital or were already seeking advice from a treating hospital clinican.
Conclusion: There is a significant burden of concern generated from the misuse of cyanogenic glycoside products for cancer prevention and treatment, which can result in hospital admission carrying significant health risk and expenditure.
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http://dx.doi.org/10.1111/1742-6723.14450 | DOI Listing |
RSC Med Chem
July 2025
Structural Bioinformatics Lab, Biotechnology division, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT) Palampur HP 176061 India
Epidermal growth factor receptor (EGFR) is a membrane-bound protein that interacts with epidermal growth factor, triggering receptor dimerization and tyrosine autophosphorylation, subsequently promoting cell proliferation. EGFR-associated pathways regulate cell housekeeping functions like growth, division, and apoptosis. However, the mutations/overexpression of EGFR cause unrestrained cell differentiation, leading to tumorigenesis.
View Article and Find Full Text PDFJ Hazard Mater
September 2025
US. Environmental Protection Agency, Office of Research and Development, Center for Environmental Measurement and Modeling, Research Triangle Park, NC 27711, USA. Electronic address:
The thermal decomposition of single-component aqueous solutions of hexafluoropropylene oxide dimer acid (HFPO-DA), a "GenX" process chemical, was investigated in a pilot-scale research combustor. Two solutions containing target HFPO-DA concentrations of ∼500 and 4000 mg/L were atomized at three post-flame temperatures of ∼920, 860, and 750 °C, during which the stack gases were characterized for combustion products including fluorocarbon products of incomplete combustion (PICs). Analytical techniques included Other Test Method 50 (OTM-50) and real-time analysis using Fourier transform infrared spectroscopy (FTIR) and chemical ionization mass spectrometry (CIMS).
View Article and Find Full Text PDFRetin Cases Brief Rep
January 2025
Eye Clinic, Department of Biomedical and Clinical Sciences, Ospedale Luigi Sacco, University of Milan, Milan, Italy.
Purpose: To describe a rare complication in a patient with extensive macular atrophy with pseudodrusen-like appearance (EMAP), suggesting immune dysregulation in advanced stages of the disease.
Methods: Case Report. Multimodal imaging -including true-color fundus photography, blue autofluorescence, high-resolution optical coherence tomography (Hi-Res OCT), swept-source OCT angiography, and dye-based angiography- was used to evaluate retinal alterations.
Appetite
November 2024
School of Medicine, Locked Bag 1797 Penrith NSW 2751, Western Sydney University, Sydney, Australia. Electronic address:
Pacific Island Countries (PICs) have exceptionally high rates of obesity and non-communicable diseases. The causes are complex but one prominent factor is the notable shift from traditional plant and seafood diets to diets high in unhealthy processed foods. Literature is sparse on the motives behind food choice decisions of Pacific Islanders.
View Article and Find Full Text PDFEmerg Med Australas
August 2024
Department of Intensive Care, Launceston General Hospital, Launceston, Tasmania, Australia.
Objective: Vitamin B17 tablets are sold (online) as an alternative cancer therapy medication. Its use however is not benign, given that it is metabolised into hydrogen cyanide. We aimed to measure the number of calls received by the New South Wales Poisons Information Centre (NSW PIC) regarding Amygdalin exposures.
View Article and Find Full Text PDF