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The Test of Adherence to Inhalers (TAI) Toolkit links an adherence measurement instrument (the TAI) to proven effective interventions for different causes of non-adherence to inhaled medication. This study aimed to assess the usability and feasibility of the TAI Toolkit in clinical practice. The TAI Toolkit was piloted in eight primary and secondary care settings. Each study site included 10 patients with asthma and/or COPD and suspected non-adherence. Healthcare professionals (HCPs) recorded clinical data and TAI Toolkit outcomes. Data on usability and feasibility were collected in semi-structured interviews and with the System Usability Score (SUS). Of the included patients, 81% were non-adherent, and sporadic non-adherence was the most common (69%). The TAI Toolkit was valued with a mean SUS-score of 85.9 by the HCPs. They found the toolkit to 'be visually attractive', 'easy-to-use' and 'give insight into patients' adherence', thereby offering good potential for its use in clinical practice.
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http://dx.doi.org/10.1038/s41533-024-00372-z | DOI Listing |
Bioinformatics
March 2025
Yazhouwan National Laboratory, Sanya 572024, China.
Summary: With the rapid development of long-read sequencing technologies, the era of individual complete genomes is approaching. We have developed wgatools, a cross-platform, ultrafast toolkit that supports a range of whole-genome alignment formats, offering practical tools for conversion, processing, evaluation, and visualization of alignments, thereby facilitating population-level genome analysis and advancing functional and evolutionary genomics.
Availability And Implementation: wgatools supports diverse formats and can process, filter, and statistically evaluate alignments, perform alignment-based variant calling, and visualize alignments both locally and genome-wide.
Bioorg Chem
April 2025
State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, 3 Taicheng Road, Yangling 712100 Shaanxi, China. Electronic address:
Benzylisoquinoline alkaloids (BIAs) constitute a vast and diverse class of plant-derived secondary metabolites, renowned for their potent therapeutic activities. O-methylation, catalyzed by O-methyltransferases (OMTs), is a prevalent feature of BIA molecules, which is intrinsically related to their bioactivities. Herein, we described the identification and characterization of two functionally identical but phylogenetically different BIA 7OMTs, SyOMT4 and SyOMT5, from the transcriptomic data of Stephania yunnanensis-a well-known anti-COVID-19 drug cepharanthine producing plant.
View Article and Find Full Text PDFArXiv
September 2024
Yazhouwan National Laboratory, 572024, Sanya, China.
NPJ Prim Care Respir Med
May 2024
Department of Clinical Pharmacy & Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
The Test of Adherence to Inhalers (TAI) Toolkit links an adherence measurement instrument (the TAI) to proven effective interventions for different causes of non-adherence to inhaled medication. This study aimed to assess the usability and feasibility of the TAI Toolkit in clinical practice. The TAI Toolkit was piloted in eight primary and secondary care settings.
View Article and Find Full Text PDFMethods Mol Biol
January 2024
Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.
ANNOgesic is an RNA-seq analysis pipeline that can detect sRNAs and many other genomic features in bacteria and archaea. In addition to listing sRNA candidates, ANNOgesic also generates various formats of data files for visual examination and downstream experimental design. Based on validations from previous studies, the sRNA predictions are accurate and reliable.
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