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http://dx.doi.org/10.1093/eurheartj/ehae283 | DOI Listing |
Cureus
March 2025
Department of Neonatology/Pediatrics, Boston Children's Health Physicians/New York Medical College, New York, USA.
Cardiovascular diseases (CVDs) are increasing in prevalence, causing significant health issues and remaining one of the leading causes of death worldwide. Medical herbs continue to be used as an alternative treatment approach for several diseases, including various CVDs. Since ancient times, certain herbs have been safely used to alleviate the risk of developing CVD and control or improve the symptoms of medical conditions, such as in cases of congestive heart failure, angina, atherosclerosis, and systolic hypertension.
View Article and Find Full Text PDFPhytother Res
March 2025
Pharmacy College of Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.
Metabolic diseases (MD), a series of chronic disorders, severely decrease the quality of life for patients but also cause a heavy economic burden. The ancient Chinese herb Pueraria Radix (PR) plays an important role in curing MD. Up to now, the bioactive compounds found in PR demonstrate effective actions in treating various metabolic disorders.
View Article and Find Full Text PDFCochrane Database Syst Rev
February 2025
Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain.
Background: Atherosclerotic cardiovascular diseases (ACVDs), a condition characterised by lipid accumulation in arterial walls, which is often exacerbated by chronic inflammation disorders, is the major cause of mortality and morbidity worldwide. Colchicine, with its first medicinal use in ancient Egypt, is an inexpensive drug with anti-inflammatory properties. However, its role in primary prevention of ACVDs in the general population remains unknown.
View Article and Find Full Text PDFPak J Pharm Sci
February 2025
The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
In recent years, several studies have shown that the stability of intestinal bacteria, which acts as a natural barrier, plays a key role fighting against cardiovascular disease. Dysbiosis of the gut microbiome can trigger inflammatory responses and oxidative stress damage, cause abnormal cholesterol metabolism and disrupt the levels of short-chain fatty acids, oxidized trimethylamine and bile acids, thus influencing the occurrence and development of atherosclerosis. Chinese medicine believes that the formation of atherosclerosis is related to the malfunction of the spleen in transportation and transformation, with the interplay of phlegm and blood stagnation being the primary pathogenesis.
View Article and Find Full Text PDFA mounting body of evidence suggests that the endoplasmic reticulum stress and the unfolded protein response are involved in the underlying mechanisms responsible for vascular diseases. Inositol-requiring protein 1α (IRE1α), the most ancient branch among the UPR-related signaling pathways, can possess both serine/threonine kinase and endoribonuclease (RNase) activity and can perform physiological and pathological functions. The IRE1α-signaling pathway plays a critical role in the pathology of various vascular diseases.
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