Pak J Pharm Sci
February 2025
In recent years, several studies have shown that the stability of intestinal bacteria, which acts as a natural barrier, plays a key role fighting against cardiovascular disease. Dysbiosis of the gut microbiome can trigger inflammatory responses and oxidative stress damage, cause abnormal cholesterol metabolism and disrupt the levels of short-chain fatty acids, oxidized trimethylamine and bile acids, thus influencing the occurrence and development of atherosclerosis. Chinese medicine believes that the formation of atherosclerosis is related to the malfunction of the spleen in transportation and transformation, with the interplay of phlegm and blood stagnation being the primary pathogenesis.
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