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The objective of this study was the evaluation of the locomotion activity of heifers and Holstein dairy cows during estrus. We have analyzed the locomotion activity using the Heatime RuminAct device on 180 cows (32 heifers and 148 dairy cows) and we evaluated a total of 633 estrus cycles during the reference period of 3 days before estrus, 3 days after estrus, and on the day ofestrus occurrence. The datawere analyzed using the DataFlowTM II program. The locomotion of cows was expressed in the units of locomotion activity in 24 h (u.24 h). During the reference period of 3 days before estrus, the cows showed locomotion activity of 558 u.24 h, with an increase in locomotion activity on the day of estrus of 836 u.24 h, and, during the reference period of 3 days after estrus, the level of locomotion activity decreased to 537 836 u.24 h, which is a similar level of locomotion activity to the reference period before estrus. Through the statistical analysis, we evaluated the impact of parity, lactation stage, milk yield, and individuality on changes in locomotion activity during estrus and throughout the reference period, and we found a significant effect of parity (F = 13.41, < 0.001) on changes in the locomotion activity of dairy cows during estrus. Based on these results, this research offers fresh perspectives on assessing specific factors affecting the locomotion activity of dairy cows during estrus through the practical application of electronic systems for estrus detection on dairy farms.
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http://dx.doi.org/10.3390/ani14101421 | DOI Listing |
BMC Neurol
September 2025
Department of Neurology, University Hospital Schleswig-Holstein, Kiel, Germany.
Background: Parkinson's disease (PD) is characterized by motor symptoms altering gait domains such as slow walking speed, reduced step and stride length, and increased double support time. Gait disturbances occur in the early, mild to moderate, and advanced stages of the disease in both backward walking (BW) and forward walking (FW), but are more pronounced in BW. At this point, however, no information is available about BW performance and disease stages specified using the Hoehn and Yahr (H&Y) scale.
View Article and Find Full Text PDFPLoS One
September 2025
Toronto Rehabilitation Institute - University Health Network, Toronto, Ontario, Canada.
Stroke significantly contributes to long-term disability, one of the problems is with impaired balance control, increasing the risk of falls. The risk of falls may be mitigated using reactive balance training (RBT) which has been shown to effectively reduce fall risk by enhancing reactive stepping following repeated balance perturbations. However, the optimal RBT intensity for people with chronic stroke remains unknown.
View Article and Find Full Text PDFPsychol Res
September 2025
Neurorehabilitation Research Center, Kio University, Nara, Japan.
The ability to detect small errors between sensory prediction in the brain and actual sensory feedback is important in rehabilitation after brain injury, where motor function needs to be restored. To date in the recent study, a delayed visual error detection task during upper limb movement was used to measure this ability for healthy participants or patients. However, this ability during walking, which is the most sought-after in brain-injured patients, was unclear.
View Article and Find Full Text PDFCancer Med
September 2025
The Key Laboratory of Tumor Stem Cell Research of Liaoning Province, Dalian Medical University, Dalian, China.
Background: Prostate cancer is one of the principal malignancies threatening human health, and the development of castration resistance often constitutes a major cause of treatment failure in its management.
Methods: To elucidate the potential association between programmed death-ligand 1 (PD-L1) and castration resistance in prostate cancer, we analyzed the expression levels of PD-L1 in both primary prostate cancer tissues and castration-resistant prostate cancer (CRPC) specimens as well as in corresponding cell lines by using western blots and immunohistochemistry. Then, we explored the specific mechanisms through transcriptomic sequencing technology.
Exp Dermatol
September 2025
Department of Surgery, Chang Bing Show Chwan Memorial Hospital, Lukang, Taiwan.
Radiation dermatitis is a common side effect of radiotherapy, affecting up to 95% of cancer patients receiving radiation therapy and often leading to skin damage, inflammation, and ulceration. The pathogenesis of radiation dermatitis involves complex mechanisms, such as the production of reactive oxygen species (ROS) and sustained inflammatory responses. Current treatments, including topical steroids, moisturisers, and non-steroidal anti-inflammatory drugs (NSAIDs), often provide limited efficacy, primarily addressing symptoms rather than the underlying pathophysiological processes.
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