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Background: Chest pain is among the most common reasons for presentation to the emergency department (ED) worldwide. Additional studies on most cost-effective ways of differentiating serious vs. benign causes of chest pain are needed.
Objectives: Our study aimed to evaluate the effectiveness of a novel risk stratification pathway utilizing 5 generation high-sensitivity cardiac troponin T assay (Hs-cTnT) and HEART score (History, Electrocardiogram, Age, Risk factors, Troponin) in assessing nontraumatic chest pain patients in reducing ED resource utilization.
Methods: A retrospective chart review was performed 6 months prior to and after the implementation of a novel risk stratification pathway that combined hs-cTnT with HEART score to guide evaluation of adult patients presenting with nontraumatic chest pain at a large academic quaternary care ED. Primary outcome was ED length of stay (LOS); secondary outcomes included cardiology consult rates, admission rates, number of ED boarders, and number of eloped patients.
Results: A total of 1707 patients and 1529 patients were included pre- and postimplementation, respectively. Median overall ED LOS decreased from 317 to 286 min, an absolute reduction of 31 min (95% confidence interval 22-41 min), after pathway implementation (p < 0.001). Furthermore, cardiology consult rate decreased from 26.9% to 16.0% (p < 0.0001), rate of admission decreased from 30.1% to 22.7% (p < 0.0001), and number of ED boarders as a proportion of all nontraumatic chest pain patients decreased from 25.13% preimplementation to 18.63% postimplementation (p < 0.0001).
Conclusions: Implementation of our novel chest pain pathway improved numerous ED throughput metrics in the evaluation of nontraumatic chest pain patients.
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http://dx.doi.org/10.1016/j.jemermed.2024.02.008 | DOI Listing |
JAMA Netw Open
September 2025
Division of Cardiology, Duke University Hospital, Durham, North Carolina.
Importance: Previous data suggest that the time changes associated with daylight savings time (DST) may be associated with an increased incidence of acute myocardial infarction (AMI).
Objective: To determine whether the incidence of patients presenting with AMI is greater during the weeks during or after DST and compare the in-hospital clinical events between the week before DST and after DST.
Design, Setting, And Participants: This cross-sectional study examined patients enrolled in the Chest Pain MI Registry from 2013 to 2022.
Catheter Cardiovasc Interv
September 2025
Escuela de Medicina, Universidad Peruana Unión, Lima, Peru.
Background: Current guidelines recommend clopidogrel in patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI), yet the comparative benefits are unclear.
Aims: The aim of this study was to evaluate the efficacy and safety of ticagrelor versus clopidogrel in patients with CCS undergoing PCI.
Methods: We searched PubMed/MEDLINE, EMBASE, CENTRAL databases from inception to February 15, 2025.
J Pain Res
September 2025
Department of National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Purpose: Intrathecal fentanyl improves intraoperative analgesia and reduces hypotension by enhancing subtherapeutic local anesthetic doses during cesarean sections. This study explores whether these advantages are affected by the negative circulatory effects of carbetocin after delivery.
Patients And Methods: This randomized double-blind, non-inferiority trial was conducted at a tertiary hospital in China.
Cureus
August 2025
Infectious Diseases, Methodist University Hospital, Memphis, USA.
Mycoplasma pneumoniae (MP) is a bacterium commonly known to cause mild respiratory infections, especially in young children. Epstein-Barr virus (EBV) is a herpesvirus that causes infectious mononucleosis, typically a mild illness in younger individuals. However, in its severe form, EBV can cause pneumonia.
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August 2025
Emergency Medicine, NMC Royal Hospital, Khalifa City, ARE.
In adults having chest pain, ST-segment elevation, both benign and pathologic, is a common finding seen on electrocardiograms (ECGs). Some degree of ST-segment elevation is common, especially in young men. Commonly referred to as benign early repolarization (BER), this elevation is seen in the precordial leads.
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